L7035

clasto-Lactacystin β-lactone

• Sinónimos: (1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-Oxa-2-Azabicyclo[3.2.0]Heptane-3,7-Dione, Omuralide
• Fórmula empírica (notación de Hill): C₁₀H₁₅NO₄
• Número de CAS: 154226-60-5
• Peso molecular: 213.23
• Número MDL: MFCD01076526
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24896450
• NACRES: NA.77

Propiedades

• Ensayo: ≥95% (HPLC)
• Nivel de calidad: 100
• Formulario: film
• solubilidad: DMSO: soluble 25 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: [H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C
• InChI: 1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1
• Clave InChI: FWPWHHUJACGNMZ-NBBQQVJHSA-N

Descripción

Aplicación

Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.

Clasto-Lactacystin β-lactone has been used as a protein degradation inhibitor to test its effect on memory improvements in mice. It has also been used as a proteasome inhibitor in human ovarian surface epithelium (HOSE) cells and dendritic cells (DCs).

Acciones bioquímicas o fisiológicas

Cell-permeable and irreversible proteasome inhibitor. Lactacystin acts as a precursor for clasto-lactacystin β-lactone.

Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii by acting in the N-threonine residue of the  β -type subunits.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H319
• Consejos de prudencia: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable