M8699
(R)-MG132
Sinónimos:
Z-L-Leu-D-Leu-L-Leu-al
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About This Item
Fórmula empírica (notación de Hill):
C26H41N3O5
Número de CAS:
Peso molecular:
475.62
UNSPSC Code:
12352200
NACRES:
NA.32
Productos recomendados
assay
≥98%
Quality Level
solubility
DMSO or DMF: 25 mg/mL
storage temp.
−20°C
SMILES string
CC(C)C[C@@H](C(N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC(C)C)=O)NC(OCC1=CC=CC=C1)=O
Application
(R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor.
Biochem/physiol Actions
MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.
Physical form
crystalline solid or supercooled liquid
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
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