Nicotinamidase/pyrazinamidase (PncA) is involved in the NAD+ salvage pathway of Mycobacterium tuberculosis and other bacteria. In addition to hydrolyzing nicotinamide into nicotinic acid, PncA also hydrolyzes the prodrug pyrazinamide to generate the active form of the drug, pyrazinoic acid, which
Journal of nanoscience and nanotechnology, 10(10), 6939-6943 (2010-12-09)
We have fabricated fluorescing polystyrene/dicyanopyrazine-linked porphyrin (PS/4-TDCPP) nanofibers using the electrospinning technique. UV-vis spectroscopy shows a strong Soret band and two relatively weak Q bands from the PS/4-TDCPP films and fibers, and reveals that the 4-TDCPP molecules are homogeneously dispersed
Acta poloniae pharmaceutica, 63(1), 39-45 (2007-05-23)
The new pyrazine derivatives exhibiting an antibacterial activity have been synthesized. Initial amidoxime 1 was obtained in the reaction of pyrazinecarbonitrile with hydroxylamine. Upon treatment of amidoxime with methyl iodide O-methyl derivative 2 was formed. Both amidoximes were transformed into
Reductive decyanation of pyrazinecarbonitriles.
Albaneze-Walker J, et al.
Tetrahedron Letters, 43(38), 6747-6750 (2002)
Surface-enhanced Raman spectra of pyrazinecarboxamide and pyrazinecarbonitrile on silver sols.
Arenas JF, et al.
Journal of Raman Spectroscopy, 23(5), 249-252 (1992)
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