切向流过滤夹具和系统
受益于我们在切向流过滤 (TFF) 方面领先的生物工艺知识和工程技术专长，我们开发了结合多项独特、创新和智能特性的多次使用性、一次性和工艺开发系统。我们的系统旨在满足切向过滤纯化的成功标准，包括低滞留体积、最大体积浓度和最佳产品回收率，以增进工艺性能。
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工艺开发TFF系统
我们的Cogent®实验室系统系列与我们的制造规模设备使用了类似的设计、传感技术和配件。我们的系统采用均匀的设计，具有20至6000 mL/min的流量范围，专门用于简化工艺开发。Cogent® Lab 150、800和6000系统经优化可实现较高的产品回收率和排水能力，确保小规模TFF操作的成功。
- 具有协调设计和线性性能的TFF系统系列可确保成功、无缝的放大或缩小
- 用户友好型的Bio4C®控制软件可提供预定义的流程步骤、实时数据可视化和导出功能，确保可靠和可重复的结果
- Cogent®实验室系统可针对您特定的工艺提供带有各种选项的定制
- 在UF/DF、微过滤或SPTFF模式下以及一系列参数范围内灵活操作
用于Pellicon® 平片式设备的固定器
我们的系统最适合与 Pellicon® 耗材一起使用, 无论是一次性（Pellicon® 囊式过滤器）还是多次使用性应用 （Pellicon® 2 和 3）。购买 TFF 系统时可包括固定器； 详情请参阅相应的数据说明书。我们提供用于过滤面积从 88 cm² 到 130 m² 不等的自立式固定器，具体取决于耗材。
- XX42PMICR0固定器用于Pellicon® 3 micro，过滤面积88 cm² 到264 cm²
- XX42PMINI固定器用于Pellicon® 2和3，过滤面积0.1 m²到0.55 m²
- Pellicon® 工业规模固定器用于 Pellicon® 2 和 3，过滤面积为 0.5 m² 及以上
还可以选择加大安装表面并在单程模式下运行的选项。
相关资源
- Perf. Guide: Mobius® TFF 80 System
This guide includes information from a number of applications and case studies that were designed and/or selected to provide a diverse overview of the system performance under a range of expected processing conditions.
- Spare Parts List: Mobius® TFF 80 System
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock. The risk assessment is based on our experience; each customer must perform their individual risk assessment for their process, to check the alignment with our strategy and review the stock requirements accordingly.
- Data Sheet: Mobius® FlexReady Solution for TFF
The Mobius® FlexReady Solution with Smart Flexware® Assemblies is flexible, allowing you to have a single system for tangential flow filtration (TFF) at various scales.
- Performance Guide: Mobius® FlexReady Solution (TF2S) with Smart Flexware® Assemblies for TFF with Closed Enabled Configuration
This Performance Guide is a reference document that provides highlights of key performance aspects of the Mobius® FlexReady Solution with Smart Flexware® Assemblies for Tangential Flow Filtration (TFF) used with a closed-enabled flowpath.
- Spec. Sheet: Mobius® FlexReady Solution with Smart Flexware® Assemblies for TFF
Flexible design options; Unique feed tank design and performance; Smart Flexware® full single-use flow paths; Excellent product recovery and purification; Implement with ease and lower risks; Full process automation with flexible recipes using the Common Control Platform® (CCP®)
- Spare Parts List: Mobius® FlexReady Solution
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock. The risk assessment is based on our experience; each customer must perform their individual risk assessment for their process, to check the alignment with our strategy and review the stock requirements accordingly.
- Data Sheet: Cogent® Process-scale Tangential Flow Filtration System
Fully automated, configurable systems for biopharmaceutical manufacturing and cGMP process scale applications
- Data Sheet: Cogent® Lab Systems
A family of modular and flexible systems for TFF at process development scale
- Spare Parts List - Cogent® Lab Systems
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock.
- Application Note: Running a TFF optimization study with Cogent® Lab Systems and Bio4C® Control Software
This application note describes the recommended methods and techniques for optimizing a tangential flow filtration (TFF) process using a Cogent® Lab system.
- Brochure: Process Development and Drug Manufacturing: Support Services
We provide comprehensive services for drug development and manufacturing, including technical and regulatory expertise and process development support.
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