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About This Item
经验公式（希尔记法）:
C20H16N2O4
CAS号:
分子量:
348.35
Beilstein:
631069
MDL號碼:
分類程式碼代碼:
41116107
NACRES:
NA.24
推荐产品
等級
primary reference standard
產品線
phyproof® Reference Substance
化驗
≥90.0% (HPLC)
形狀
powder
製造商／商標名
PhytoLab
mp
260 °C (dec.) (lit.)
儲存溫度
2-8°C
SMILES 字串
CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O
InChI
1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
InChI 密鑰
VSJKWCGYPAHWDS-FQEVSTJZSA-N
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一般說明
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
應用
- Co-delivery system for camptothecin and doxorubicin: Research on dendritic polymer prodrug-based unimolecular micelles demonstrated a pH-responsive co-delivery mechanism for camptothecin and doxorubicin, offering a synergistic effect in controlled drug release (Chen and Liu, 2024).
- Investigation into camptothecin′s role in chronic myeloid leukemia: The study explored the therapeutic potential of FL118, a camptothecin derivative, against chronic myeloid leukemia resistant to BCR-ABL inhibitors, targeting RNA helicase DDX5 (Takeda et al., 2024).
法律資訊
phyproof is a registered trademark of PhytoLab GmbH & Co. KG
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - Muta. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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分析证书(COA)
Lot/Batch Number
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Raju Suresh Kumar et al.
Saudi journal of biological sciences, 27(12), 3290-3300 (2020-12-12)
A small library of cage-like heterocyclic hybrids encompassing pyrroloisoquinolines, pyridinone and acenaphthene structural moieties have been synthesized and tested for their potential as anticancer agents against HCT116 and JURKAT cell lines. The results revealed that these cell lines are more
Katerina D Fagan-Solis et al.
Cell reports, 30(5), 1385-1399 (2020-02-06)
The Mre11-Rad50-Nbs1 complex is a DNA double-strand break sensor that mediates a tumor-suppressive DNA damage response (DDR) in cells undergoing oncogenic stress, yet the mechanisms underlying this effect are poorly understood. Using a genetically inducible primary mammary epithelial cell model
Jun Ho Ko et al.
Cell reports, 33(12), 108543-108543 (2020-12-29)
DNA damage tolerance (DDT) and homologous recombination (HR) stabilize replication forks (RFs). RAD18/UBC13/three prime repair exonuclease 2 (TREX2)-mediated proliferating cell nuclear antigen (PCNA) ubiquitination is central to DDT, an error-prone lesion bypass pathway. RAD51 is the recombinase for HR. The
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