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主要文件

577515-U

Supelco

Cyano HPLC 色谱柱 ®

5 μm particle size, L × I.D. 2 cm × 3 mm

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About This Item

分類程式碼代碼:
41115700
eCl@ss:
32110501

材料

stainless steel column

agency

suitable for USP L10

產品線

Discovery®

特點

endcapped

製造商／商標名

Discovery®

包裝

1 ea of

標籤範圍

4.5% Carbon loading

參數

≤70 °C temp. range
400 bar pressure (5801 psi)

技術

HPLC: suitable
LC/MS: suitable

長度 × 內徑

2 cm × 3 mm

表面積

200 m2/g

表面覆盖率

3.5 μmol/m2

雜質

<10 ppm metals

基質

silica gel, high purity, spherical base material
fully porous particle

基質活性組

cyano phase

粒徑

5 μm

孔徑

180 Å

工作pH值範圍

2-8

應用

food and beverages

分離技術

hydrophilic interaction (HILIC)
normal phase
reversed phase

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特點和優勢

  • 低疏水性可实现对疏水性化合物的快速洗脱
  • 分析强碱性化合物具有优良的峰形和保留性能
  • 对极性化合物具有较强的保留能力
  • 独特的选择性
  • 保留时间显著小于 C18 柱（通常流动相中所需有机相比例更低）
  • 稳定性好、低流失，适用于 LC-MS 分析
  • 与高含水量的流动相兼容

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法律資訊

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
K Umekawa et al.
Japanese journal of pharmacology, 84(1), 7-15 (2000-10-24)
We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung microsomes with an IC50 value of 42 nM and, at 10 - 100 microM, had no effect on other
Christophe Morisseau et al.
Analytical biochemistry, 414(1), 154-162 (2011-03-05)
The microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics. In addition, it has a potential role in sexual development and bile acid transport, and it is associated with a number of diseases such as
Srdan Verstovsek et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(3), 788-796 (2008-02-05)
The discovery of an activating somatic mutation in codon 617 of the gene encoding the Janus kinase (JAK)-2 (JAK2 V617F) in patients with myeloproliferative disorders has opened new avenues for the development of targeted therapies for these malignancies. However, no
T A Verdoorn et al.
European journal of pharmacology, 269(1), 43-49 (1994-09-15)
The diversity of neuronal glutamate receptors continues to increase with the discovery of multiple subunits and subunit families. The significance of this potential receptor heterogeneity is unknown because pharmacological tools that could clearly distinguish between different structural isoforms have not
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Discovery® HPLC Columns for Fast LC-MS Analysis

Discovery® HPLC Columns for Fast LC-MS Analysis. The Discovery LC-MS line offers short length columns for fast LC-MS analysis that are rugged and dependable. Supelco offers a robust product that withstands column shock due to fast gradient turnaround times.

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