推荐产品
产品名称
Ascentis® Express RP-Amide，2.7 μm保护柱芯, 2.7 μm particle size, L × I.D. 5 mm × 4.6 mm, pkg of 3 ea
物料
stainless steel column
质量水平
Agency
suitable for USP L60
产品线
Ascentis®
特点
endcapped
包装
pkg of 3 ea
技术
HPLC: suitable
LC/MS: suitable
长度 × 内径
5 mm × 4.6 mm
表面积
135 m2/g
基质
Fused-Core® particle platform
superficially porous particle
基质活性基团
amide, alkyl phase
粒径
2.7 μm
孔径
90 Å
工作pH值
2-9
应用
food and beverages
分离技术
reversed phase
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一般描述
Ascentis Express保护柱可为昂贵的分析柱提供物理（过滤）和化学保护，而不会损害Ascentis Express柱的超高性能。这些Ascentis Express保护柱仅需用手拧紧即可在高达9000 psi（600 bar）的压力下连续使用。无需从流路中卸下保护柱套即可轻松更换保护柱芯。柱芯中填充有Ascentis Express Fused-Core®颗粒。单独订购保护柱套。
应用
- 聚己内酯复合微/纳米纤维材料作为限进介质的替代品，用于使用柱切换色谱法从人血清中直接提取和分离非甾体抗炎药: 本研究利用Ascentis Express RP Amide，证明了其在柱切换色谱法中直接从人血清中提取和分离非甾体抗炎药的有效性。该研究强调了该柱在处理复杂生物基质方面的实用性，这是药代动力学和药物监测研究的一个重要方面（Raabova et al., 2021）。
- 用于定量测定大鼠血浆中新型乙酰胆碱酯酶抑制剂PC 48（7-MEOTA-多奈哌齐样化合物）的HPLC-MS法：药代动力学研究的应用: 本论文详细介绍了Ascentis Express RP Amide在经过验证的HPLC-MS方法中的应用，用于分析大鼠血浆中的新型乙酰胆碱酯酶抑制剂PC 48。该方法在药代动力学研究的应用强调了其在新药开发和治疗监测中的重要性（Mzik et al., 2016）。
- 利用熔融核柱的在线SPE-UHPLC法提取分离含辣椒调味品中的9种非法染料: 本研究证明了Ascentis Express RP Amide的多功能性，采用在线固相萃取（SPE）柱结合UHPLC检测食品样品中的非法染料。该方法的稳健性和高处理能力使其成为确保食品安全和遵守监管标准的理想选择（Khalikova et al., 2014）。
法律信息
Ascentis is a registered trademark of Merck KGaA, Darmstadt, Germany
Fused-Core is a registered trademark of Advanced Materials Technology, Inc.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Michael T Furlong et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 926, 36-41 (2013-04-02)
Clopidogrel is prescribed for the treatment of Acute Coronary Syndrome and recent myocardial infarction, recent stroke, or established peripheral arterial disease. A sensitive and reliable high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay was developed and validated to enable reliable
Hirotaka Kushida et al.
Biomedical chromatography : BMC, 27(12), 1647-1656 (2013-07-03)
Uncaria Hook (UH) alkaloids are involved in the beneficial effects of Yokukansan. However, the pharmacokinetics of UH alkaloids after oral administration of Yokukansan has not yet been sufficiently investigated. Therefore, we developed and validated a sensitive and specific high-performance liquid
Martin Mzik et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1020, 85-89 (2016-04-01)
A simple, rapid and sensitive method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed and validated for the quantitative determination in rat plasma of a new candidate for AD treatment, namely PC 48 (a 7-MEOTA-donepezil like compound) in
Erzsébet Oláh et al.
Journal of chromatography. A, 1217(23), 3642-3653 (2010-04-23)
Today sub-2 microm packed columns are very popular to conduct fast chromatographic separations. The mass-transfer resistance depends on the particle size but some practical limits exist not to reach the theoretically expected plate height and mass-transfer resistance. Another approach applies
Maria A Khalikova et al.
Talanta, 130, 433-441 (2014-08-28)
The presented work describes the development of a simple, fast and effective on-line SPE-UHPLC-UV/vis method using fused core particle columns for extraction, separation and quantitative analysis of the nine illegal dyes, most frequently found in chilli-containing spices. The red dyes
商品
Improve your separation of basic compounds with our Ascentis® Express RP-Amide HPLC columns from the Supelco® portfolio.
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