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Merck
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文件

W104

Sigma-Aldrich

WIN 62,577

solid

别名:

17-β-Hydroxy-17-α-ethynyl-δ-4-androstano[3,2-b]pyrimido[1,2-a]benzimidazole

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About This Item

经验公式（希尔记法）:
C29H31N3O
CAS号:
138091-43-7
分子量:
437.58
MDL號碼:
MFCD00153883
分類程式碼代碼:
12352200
PubChem物質ID:
24278780
NACRES:
NA.77

形狀

solid

顏色

yellow

溶解度

ethanol: 1.4 mg/mL
DMSO: 4 mg/mL
H2O: insoluble

儲存溫度

−20°C

SMILES 字串

[H][C@@]12CCC3=Cc4nc5nc6ccccc6n5cc4C[C@]3(C)[C@@]1([H])CC[C@@]7(C)[C@@]2([H])CC[C@@]7(O)C#C

InChI

1S/C29H31N3O/c1-4-29(33)14-12-22-20-10-9-19-15-24-18(16-27(19,2)21(20)11-13-28(22,29)3)17-32-25-8-6-5-7-23(25)30-26(32)31-24/h1,5-8,15,17,20-22,33H,9-14,16H2,2-3H3/t20-,21+,22+,27+,28+,29+/m1/s1

InChI 密鑰

YBCYJDNOPAFFOW-XOAARHKISA-N

基因資訊

human ... TACR1(6869)
rat ... Tacr1(24807)

生化／生理作用

Non-peptide NK1 tachykinin receptor antagonist.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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K C Appell et al.
Molecular pharmacology, 41(4), 772-778 (1992-04-01)
125I-Bolton-Hunter-substance P (125I-BH-SP) binding properties of three novel classes of neurokinin-1 (NK-1) receptor antagonists were investigated in tissues derived from humans, guinea pigs, and rats. 125I-BH-SP was shown to bind to a single class of binding sites, with similar dissociation
B R Venepalli et al.
Journal of medicinal chemistry, 35(2), 374-378 (1992-01-24)
Several heterosteroids containing a dihydroethisterone skeleton were prepared and shown to displace substance P in a receptor binding assay. Further biochemical (kinetic and Scatchard analyses) and pharmacological evaluation (substance P-induced plasma extravasation and salivation in the rat) of a representative

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