V106

R(+)-维拉帕米 单盐酸盐 水合物

≥98% (HPLC), powder

• 经验公式（希尔记法）: C₂₇H₃₈N₂O₄ · HCl · xH₂O
• CAS号: 38176-02-2
• 分子量: 491.06 (anhydrous basis)
• EC 号: 205-800-5
• MDL编号: MFCD11046028
• UNSPSC代码: 12161501
• PubChem化学物质编号: 24900706
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: powder
• 旋光性: [α]22/D +9.6°, c = 0.5 in ethanol(lit.)
• 储存条件: desiccated
• 颜色: white
• 溶解性: H₂O: >30 mg/mL; ethanol: soluble
• SMILES字符串: O.Cl.COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
• InChI: 1S/C27H38N2O4.ClH.H2O/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H;1H2/t27-;;/m1../s1
• InChI key: ICKXRKHJKXMFLR-KFSCGDPASA-N

说明

应用

R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.

生化/生理作用

Inhibitor of P-glycoprotein; less active enantiomer of (±)-verapamil.

Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.

注意

hygroscopic

安全信息

• 象形图: GHS06
• 警示用语：: Danger
• 危险声明: H301 + H311 + H331
• 预防措施声明: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• 危险分类: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges