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About This Item
经验公式（希尔记法）:
C30H49N9O9
CAS号:
分子量:
679.76
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
推荐产品
产品名称
Thymopentin, ≥97% (HPLC)
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white
应用
cell analysis
储存温度
−20°C
SMILES字符串
CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
InChI
1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1
InChI key
PSWFFKRAVBDQEG-YGQNSOCVSA-N
Amino Acid Sequence
Arg-Lys-Asp-Val-Tyr
一般描述
Thymopentin (TP5) is a pentapeptide produced by the epithelial cells of the thymic cortex and medulla. It consists of thymosin α1 (Tα1).
生化/生理作用
Thymopentin (TP5) is an immunomodulator, resembling the active site of the thymopoietin. TP5 stimulates cellular immune responses such as T-cell formation, natural killer (NK) cell and macrophage activation, generation of cytokines, and activation of B-cell for antibody production. It also mimics the polypeptide environment of the thymus. TP5 is used to treat conditions like immune deficiency, autoimmune diseases, infections, and cancers. It has a short half-life and is rapidly metabolized in the gastrointestinal tract.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
G Goldstein et al.
Survey of immunologic research, 4 Suppl 1, 1-10 (1985-01-01)
Thymopoietin is a polypeptide hormone of the thymus consisting of 49 amino acids. The pentapeptide thymopentin (TP-5) Arg-Lys-Asp-Val-Tyr, corresponding to amino acids 32-36 of thymopoietin, appears to represent the active site of thymopoietin in that it has all the biological
Jing Gao et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 36(4-5), 572-579 (2009-01-13)
Thymopentin (TP5), a synthetic pentapeptide, has been used in clinic as a modulator for immunodeficiences through intramuscular administration. The purpose of this study was to design and evaluate dry powder inhalations (DPIs) for pulmonary delivery of TP5. Dry powder inhalations
Lei Wang et al.
International journal of pharmaceutics, 375(1-2), 1-7 (2009-05-16)
The present work describes a new dry powder containing thymopentin (TP5) suitable for inhalation. A total of 21 dry powders were produced by co-spray drying TP5 with lactose or mannitol as a bulking agent, leucine as a dispersibility enhancer and
Yan Zhang et al.
International journal of pharmaceutics, 386(1-2), 15-22 (2009-11-10)
Copolymers were synthesized by ring opening polymerization of l- or d-lactide in the presence of dihydroxyl PEG with molar mass of 6000, 12,000 and 20,000, using zinc lactate as catalyst. Bioresorbable hydrogels were obtained by mixing PLLA-PEG-PLLA and PDLA-PEG-PDLA aqueous
E Sundal
The British journal of clinical practice, 47(4), 198-204 (1993-07-01)
Present immunological methods do not regularly detect abnormalities in patients with chronic bronchitis, and no single parameter appears to be closely associated with the clinical findings. Of the many tests performed in the cited studies, the Merieux multitest procedure seems
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