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生物源
Porcine (Platelets)
品質等級
化驗
≥97% (SDS-PAGE and N-terminal analysis)
形狀
powder
效力
0.05-0.5 ng/mL ED50/EC50
分子量
protein 25 kDa
包裝
pkg of 1 μg
儲存條件
avoid repeated freeze/thaw cycles
技術
cell culture | mammalian: suitable
雜質
endotoxin, tested
UniProt登錄號
儲存溫度
−20°C
基因資訊
pig ... TGFB2(397084)
一般說明
TGF-β2 (transforming growth factor-β2) belongs to the TGF-β superfamily and the gene is mapped to pig (Sus scrofa) chromosome 10p16.
生化／生理作用
TGF-β2 is responsible for maintaining immune homeostasis. TGF-β2 promotes cellular growth, differentiation and survival. TGF-β2 controls lymphocyte proliferation, apoptosis, hematopoiesis, and embryogenesis. TGF-β2 is a tumor suppress or in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF-β2 prevents NK (natural killer) cells growth as well as B and T cell proliferation. TGF-β2 also greatly inhibits the growth of both normal and transformed epithelial. The growth of lymphoid, fibroblast and keratinocyte cells are also known to be hinder by TGF-β2. TGF-β2 controls intestinal homeostasis by functioning in synergy with the bacterial lipopolysaccharide and thereby maintain interleukin-8.
TGF-β2, like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.
TGF-β2 belongs to the TGF-β superfamily. TGF-β2 is important for immune homeostasis by balancing lymphocyte proliferation, apoptosis, hematopoiesis, and embryogenesis. TGF-β2 is crucial in cell growth, differentiation, and survival. TGF-β2 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblast, and keratinocyte cells. TGF-β2 is a tumor suppress or in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF-β2 inhibits NK cells growth as well as B and T cell proliferation.
TGF-β2 belongs to the TGF-β superfamily. TGF-β2 is important for immune homeostasis by balancing lymphocyte proliferation, apoptosis, hematopoiesis, and embryogenesis. TGF-β2 is crucial in cell growth, differentiation, and survival. TGF-β2 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblast, and keratinocyte cells. TGF-β2 is a tumor suppress or in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF-β2 inhibits NK cells growth as well as B and T cell proliferation.
TGF-β2, like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.
外觀
Lyophilized from a 0.2 μm filtered solution in 25% acetonitrile and 0.1% trifluoroacetic acid containing 0.05 mg bovine serum albumin.
分析報告
The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.
The biological activity of porcine TGF-β2 was tested in culture by measuring its ability to inhibit thymidine incorporation in the IL-4 dependent mouse T-helper cell line HT-2. The EC50 is defined as the effective concentration of growth factor that elicits 50% inhibition of cell growth in a cell based bioassay.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
A Signaling Pathway Involving TGF-β2 and Snail in Hair Follicle Morphogenesis
Jamora C, et al.
PLoS Biology, 3.1 (2004)
Transforming growth factor-2 and endotoxin interact to regulate homeostasis via interleukin-8 levels in the immature intestine
Nguyen DN, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 307, G689- G699 (2014)
Transforming growth factor-? induces epithelial to mesenchymal transition and suppresses the proliferation and transdifferentiation of cultured human pancreatic duct cells.
Hong OK, Shin JA, Lee HJ, Jeon SY
Journal of Cellular Biochemistry (2010)
Mapping of the porcine urate oxidase and transforming growth factor β 2 genes by fluorescence in situ hybridization.
Rettenberger G, et al.
Chromosome Research, 4(2), 147-150 (1996)
Curcumin suppresses doxorubicin-induced epithelial?mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells.
Chen WC, et al.
Journal of Agricultural and Food Chemistry, 61(48), 11817-11824 (2013)
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