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Merck
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文件

T1157

Sigma-Aldrich

(+)-α-生育酚乙酸酯

BioReagent, suitable for insect cell culture, ~1360 IU/g

别名:

维生素 E 醋酸酯

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About This Item

经验公式（希尔记法）:
C31H52O3
CAS号:
58-95-7
分子量:
472.74
EC號碼:
200-405-4
MDL號碼:
MFCD00072052
分類程式碼代碼:
12352205
eCl@ss:
34058007
PubChem物質ID:
24899940
NACRES:
NA.75

生物源

plant

描述

Synthesized from natural α-tocopherol

產品線

BioReagent

形狀

liquid (or semi-solid)

比活性

~1360 IU/g

分子量

Mw 472.74 g/mol

純化經由

crystallization

技術

cell culture | insect: suitable

顏色

white to yellow

溶解度

chloroform: soluble 50 mg/mL, clear, colorless to yellow

儲存溫度

room temp

SMILES 字串

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

InChI 密鑰

ZAKOWWREFLAJOT-CEFNRUSXSA-N

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相关类别

一般說明

α-生育酚乙酸酯是天然存在 α-生育酚的半合成醋酸酯。

應用

在昆虫细胞培养中用作抗氧化剂。
（+）-α生育酚乙酸酯用于：
  • 作为补充剂，用于培养人胚胎肾细胞（HEK 293），评估其对细胞生长的影响
  • 作为组成成分，用于Dulbecco′s改良Eagle培养基/营养混合物F-12（DMEM / F12），培养永生化软骨细胞系
  • 作为无血清培养基成分，用于培养人类结肠组织器官
  • 试验其对牛关节软骨细胞的抗氧化作用

生化／生理作用

α-生育酚乙酸酯或维生素E-乙酸酯具有抗氧化性能，减少脂质过氧化。不过，维生素E乙酸酯热分解会导致产生烯烃和苯之类致癌物。

注意

因为熔点约为 25℃，所以这种制剂通常是油。不发生空气氧化。

危險聲明

H413

防範說明

P273 - P501

危險分類

Aquatic Chronic 4

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

個人防護裝備

Eyeshields, Gloves

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Optimization of HEK 293 cell growth by addition of non-animal derived components using design of experiments.
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Role of vitamin E-acetate on cisplatin induced genotoxicity: An in vivo analysis
Mazumdar M, et al.,
Central European Journal of Biology, 7(2), 334-342 (2012)
Horst Claassen et al.
Cell and tissue research, 319(3), 439-445 (2005-01-26)
Osteoarthritis (OA) is aggravated in menopausal women possibly because of changed serum estrogen levels. Estradiol has been postulated to affect oxidative stress induced by reactive oxygen species (ROS) in articular chondrocytes. We generated ROS in cultured bovine articular chondrocytes by
Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 47(1), 32-38 (2010-11-26)
We have recently shown that a multi-mineral extract from the marine red algae, Lithothamnion calcareum, suppresses colon polyp formation and inflammation in mice. In the present study, we used intact human colon tissue in organ culture to compare responses initiated
Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 46(2), 114-122 (2009-11-17)
Normal and neoplastic human colon tissue obtained at surgery was used to establish conditions for organ culture. Optimal conditions included an atmosphere of 5% CO2 and 95% O2; tissue partially submerged with mucosa at the gas interface; and serum-free medium
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