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生物源
human
重組細胞
expressed in E. coli
化驗
≥95% (HPLC)
≥95% (SDS-PAGE)
形狀
lyophilized
效力
≥0.5 ng/mL
分子量
19.7 kDa
包裝
pkg of 25 μg
雜質
<0.1 EU/μg endotoxin, tested
顏色
white to off-white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... FGF4(2249)
一般說明
The FGF4 (fibroblast growth factor 4) gene is mapped to human chromosome 11q13.3. It is expressed during early embryonic development. In adults, it is strongly expressed in the testis. The encoded protein mainly interacts with FGFR1c (FGF receptor 1c) and FGFR2c. It also binds to FGFR3c and FGFR4, but to a lesser extent.
應用
- FGF-4 human has been used to study the effect of FGF4 on the differentiation of PDMCs (placenta-derived multipotent cells) into hepatocyte-like cells.
- It has been used as a growth factor to study the proliferation and differentiation of human bone marrow mesenchymal stem cells (hMSCs) to chondrocytes.
- It has been used to study hepatic differentiation.
生化／生理作用
FGF4 (fibroblast growth factor 4) was first identified as an oncogene transforming NIH3T3 (mouse embryo fibroblast cell line) cells. It helps in maintaining the self-renewal capability of normal stem cells (for instance, trophoblastic stem cells). It is also required for cellular differentiation, morphogenesis and proliferation. It controls proliferation and differentiation of normal stem cells, progenitor cells and cancer cells.
外觀
Lyophilized from 10 mM Sodium Phosphate, pH 7.6 + 100 mM NaCl.
重構
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Isolation and characterization of epithelial progenitor cells from human fetal liver.
Liu YN, et al.
Hepatology Research : the Official Journal of the Japan Society of Hepatology, 38, 103-103 (2008)
Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
Yasuda K, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 94, 1355-1355 (2014)
Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis.
Grillo L, et al.
Gene, 534, 435-435 (2014)
Chondrogenic induction of human mesenchymal stem cells using combined growth factors for cartilage tissue engineering.
Bosetti M, et al.
Journal of Tissue Engineering and Regenerative Medicine, 6, 205-205 (2012)
FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner.
Johannesson M, et al.
PLoS ONE, 4, e4794-e4794 (2009)
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