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SML3483

Sigma-Aldrich

Dimethylaminoparthenolide

≥98% (HPLC)

别名:

(1aR,4E,7aS,8S,10aS,10bR)-8-[(Dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyloxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, DMAPT

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About This Item

经验公式（希尔记法）:
C17H27NO3
CAS号:
870677-05-7
分子量:
293.40
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

-10 to -25°C

SMILES 字串

C/C1=C\CC[C@](O2)(C)[C@@]2([H])[C@@H](OC([C@@H]3CN(C)C)=O)[C@@]3([H])CC1

生化／生理作用

Dimethylaminoparthenolide (DMAPT) is a water-soluble analogue of parthenolide that exhibits anti-inflammatory and anti-tumor activities. It directly binds to ribosomal protein L10 (RPL10) leading to decrease the expression of either p65 or IKKγ in varies pancreatic cancer cells. Dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma (NSCLC) by inhibition of the canonical NF-κB pathway.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H317

危險分類

Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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NF-?B inhibition by dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma by blocking DNA double-strand break repair.
Cell death discovery, 4, 10-10 (2018)
Cooperative down-regulation of ribosomal protein L10 and NF-?B signaling pathway is responsible for the anti-proliferative effects by DMAPT in pancreatic cancer cells.
Shi C, Wang Y, Guo Y, Chen Y, Liu N.
Oncotarget, 8, 35009-35018 (2017)
DMAPT is an Effective Radioprotector from Long-Term Radiation-Induced Damage to Normal Mouse Tissues In Vivo.
Morel KL, Ormsby RJ, Klebe S, Sweeney CJ, Sykes PJ.
Radiation Research, 192, 231-239 (2019)

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