SML3217

PF-06843195

≥98% (HPLC), storage temp.:2-8°C

• 别名: 2,2-Difluoroethyl (3S)-3-[[2′-amino-5-fluoro-2-(4-morpholinyl)[4,5′-bipyrimidin]-6-yl]amino]-3-(hydroxymethyl)-1-pyrrolidinecarboxylate, PF 06843195, PF 06862309 active drug, PF-06862309 active drug, PF06843195
• 经验公式（希尔记法）: C₂₀H₂₅F₃N₈O₄
• CAS号: 2067281-51-8
• 分子量: 498.46
• UNSPSC代码: 12352107
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 储存温度: 2-8°C
• SMILES字符串: OC[C@]1(CN(CC1)C(OCC(F)F)=O)NC2=NC(N3CCOCC3)=NC(C4=CN=C(N)N=C4)=C2F
• InChI key: RTOREZYNLPQUKM-FQEVSTJZSA-N

说明

生化/生理作用

PF-06843195 is a potent and PI3K-alpha subtype-selective phosphoinositide 3-kinase (PI3K) inhibitor (rat PI3K Ki = 2 nM/β, <18 nM/α, <280 nM/δ) that inhibits cellular PI3Kα activity at a higher potency over that of PI3Kδ/β and mTOR (AKT pT308 IC50 = 18/160/360 nM in rat PI3Kα/δ/β Rat1 lines; p70S6K pT389 IC50 = 1.5 μM in Rat1 myristoylated PI3K line). PF-06843195 is more potent against cellular AKT pT308 (MCF7/T47D IC50 = 7.8/8.7 nM) and proliferation (MCF7/T47D = 62/32 nM) than alpelisib (BYL719) in cultures.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable