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Merck
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文件

SML2929

Sigma-Aldrich

Bilastine

≥98% (HPLC)

别名:

2-[4-(2-(4-(1-(2-ethoxyethyl)benzimidazole-2-yl)piperidine-1-yl)ethyl)phenyl]-2-methyl-propanoic acid, 4-[2-[4-[1-(2-Ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinyl]ethyl]-α,α-dimethylbenzeneacetic acid, F-96221-BM1

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About This Item

经验公式（希尔记法）:
C28H37N3O3
CAS号:
202189-78-4
分子量:
463.61
MDL號碼:
MFCD09837814
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

InChI

1S/C28H37N3O3/c1-4-34-20-19-31-25-8-6-5-7-24(25)29-26(31)22-14-17-30(18-15-22)16-13-21-9-11-23(12-10-21)28(2,3)27(32)33/h5-12,22H,4,13-20H2,1-3H3,(H,32,33)

InChI 密鑰

ACCMWZWAEFYUGZ-UHFFFAOYSA-N

生化／生理作用

Bilastine is an orally available, potent and selective histamine H1 receptor antagonist that exhibits long drug-target residence time at H1 receptor (73 min), which results in extended H1 receptor antagonism in vitro. Bilastine is used for treatment of allergic rhinitis and urticaria (hives).

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Reyes Corcóstegui et al.
Drugs in R&D, 6(6), 371-384 (2005-11-09)
This study aimed to establish the receptor selectivity and antihistaminic activity of bilastine, a new selective antihistamine receptor antagonist. In vitro experiments were conducted using a receptor binding screening panel and guinea-pig and rat tissues. Antihistaminic activity was determined using
Xue Yan Wang et al.
Therapeutics and clinical risk management, 12, 585-597 (2016-04-26)
Allergic rhinitis and urticaria are common allergic diseases that may have a major negative impact on patients' quality of life. Bilastine, a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged
Reggie Bosma et al.
European journal of pharmacology, 838, 107-111 (2018-09-12)
Drug-target binding kinetics has recently attracted considerable interest in view of the potential predictive power for in vivo drug efficacy. The recently introduced antihistamine bilastine has a long duration of in vivo drug action, which outlasts pharmacological active bilastine concentrations

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