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Merck
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文件

SML2789

Sigma-Aldrich

tBPC

≥98% (HPLC)

别名:

2-[4-(1,1-Dimethylethyl)phenoxy]cyclohexanol

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About This Item

经验公式（希尔记法）:
C16H24O2
CAS号:
1942-71-8
分子量:
248.36
MDL號碼:
MFCD00155433
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

InChI

1S/C16H24O2/c1-16(2,3)12-8-10-13(11-9-12)18-15-7-5-4-6-14(15)17/h8-11,14-15,17H,4-7H2,1-3H3

InChI 密鑰

FTIXUILRMBSXNS-UHFFFAOYSA-N

生化／生理作用

tBPC is a postitive allosteric modulator of the neuropeptide Y (NPY) Y4 receptor, which is predominantly expressed in the gastrointestinal tract and activated most strongly by pancreatic polypeptide (PP). tBPC was shown to potentiate Y4R activity in G-Protein signaling and arrestin3 recruitment and to potentiate the native PP response. tBPC was selective for Y4R over other Neuropeptide Y receptors and showed no effect on the efficacy (Emax) or potency (EC50) of the NPY signal response at the Y1, Y2, or Y5 receptors at 30 μM.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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Mario Schubert et al.
Journal of medicinal chemistry, 60(17), 7605-7612 (2017-08-11)
The human Y4 receptor (Y4R) and its cognate ligand, pancreatic polypeptide (PP), are involved in the regulation of energy expenditure, satiety, and food intake. This system represents a potential target for the treatment of metabolic diseases and has been extensively

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