推荐产品
方案
≥98% (HPLC)
表单
oil
颜色
colorless to light brown
储存温度
2-8°C
SMILES字符串
O=C(CC(C)C)C1=CC=C(OC(F)F)C(OC2CCOC2)=C1
InChI key
IXURVUHDDXFYDR-UHFFFAOYSA-N
生化/生理作用
Roflupram（FFPM）是有效的抗炎性磷酸二酯酶4（PDE4）抑制剂，可通过增强自噬抑制小胶质细胞炎性体活化。在小胶质细胞BV-2中，roflupram提高了微管相关蛋白1轻链3 Ⅱ（LC3-II）的水平，降低了自噬受体泛素结合蛋白p62（SQSTM1），从而增强自噬、降低炎性体的活化、抑制IL-1β的产生。 发现roflupram（FFPM）可以逆转APP/PS1转基因小鼠的学习和记忆缺陷。
抗炎性磷酸二酯酶4（PDE4）抑制剂
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Tingting You et al.
ACS chemical neuroscience, 8(11), 2381-2392 (2017-06-13)
Inhibition of phosphodiesterase 4 (PDE4) suppressed the inflammatory responses in the brain. However, the underlying mechanisms are poorly understood. Roflupram (ROF) is a novel PDE4 inhibitor. In the present study, we found that ROF enhanced the level of microtubule-associated protein
Hui-Fang Tang et al.
International immunopharmacology, 10(4), 406-411 (2010-01-16)
In the present study, we investigated the effect of classic PDE4 inhibitor rolipram and novel PDE4 inhibitor ZL-n-91 on LPS-induced acute lung injury (ALI) in mice and its mechanism. ALI was induced in ICR mice by instilling intratracheally with LPS
Shilong Zheng et al.
Journal of medicinal chemistry, 51(24), 7673-7688 (2008-12-04)
Phosphodiesterase 4 catalyzes the hydrolysis of cyclic AMP and is a target for the development of anti-inflammatory agents. We have designed and synthesized a series of phenyl alkyl ketones as PDE4 inhibitors. Among them, 13 compounds were identified as having
Haibiao Guo et al.
Neuropharmacology, 116, 260-269 (2017-01-10)
Thus far, phosphodiesterase-4 (PDE4) inhibitors have not been approved for application in Alzheimer's disease (AD) in a clinical setting due to severe side effects, such as nausea and vomiting. In this study, we investigated the effect of FFPM, a novel
Dan Li et al.
International immunopharmacology, 90, 107176-107176 (2020-11-28)
Roflupram (ROF) is a novel phosphodiesterase 4 inhibitor. We previously found that ROF suppressed the production of pro-inflammatory factors in microglial cells; however, the underlying mechanisms are largely unknown. The present study aimed to elucidate the underlying molecular mechanisms of
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