推荐产品
product name
布美他尼, ≥98%
化驗
≥98%
形狀
powder
起源
Roche
SMILES 字串
CCCCNc1cc(cc(c1Oc2ccccc2)S(N)(=O)=O)C(O)=O
InChI
1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)
InChI 密鑰
MAEIEVLCKWDQJH-UHFFFAOYSA-N
基因資訊
human ... SLC12A1(6557)
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生化／生理作用
Na + /K + /Cl - 协同转运蛋白抑制剂。
特點和優勢
这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Wolfgang Löscher et al.
Neuropharmacology, 69, 62-74 (2012-06-19)
In cortical and hippocampal neurons, cation-chloride cotransporters (CCCs) control the reversal potential (EGABA) of GABAA receptor-mediated current and voltage responses and, consequently, they modulate the efficacy of GABAergic inhibition. Two members of the CCC family, KCC2 (the major neuron-specific K-Cl
Mark H Pitcher et al.
The journal of pain : official journal of the American Pain Society, 14(1), 57-65 (2012-12-04)
Stimulation of peripheral nociceptors results in increased c-Fos labeling in spinal cord regions associated with nociceptive processing. Accordingly, intracolonic capsaicin, which generates robust secondary (referred) allodynia on the abdomen of mice, also causes an increased spinal c-Fos labeling. In naïve
Jiajie Shan et al.
The Journal of physiology, 590(21), 5273-5297 (2012-07-11)
Anion and fluid secretion are both defective in cystic fibrosis (CF); however, the transport mechanisms are not well understood. In this study, Cl(-) and HCO(3)(-) secretion was measured using genetically matched CF transmembrane conductance regulator (CFTR)-deficient and CFTR-expressing cell lines
Ernesto Vargas et al.
The Journal of physiology, 591(1), 57-65 (2012-09-26)
The expression of Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) is responsible for high intracellular Cl(-) resulting in the excitatory action of GABA(A) receptor activation in the developing brain. Giant depolarizing potentials (GDPs) are spontaneous network oscillations that involve GABA(A) receptors and are thought
Jun Wang et al.
Journal of neuroinflammation, 19(1), 91-91 (2022-04-14)
The mechanisms underlying dysfunction of choroid plexus (ChP) blood-cerebrospinal fluid (CSF) barrier and lymphocyte invasion in neuroinflammatory responses to stroke are not well understood. In this study, we investigated whether stroke damaged the blood-CSF barrier integrity due to dysregulation of
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