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生化／生理作用
A-395N is a control probe for A-395, which is a chemical probe for polycomb protein EED. A-395 is a potent and selective chemical probe for the polycomb protein EED (embryonic ectoderm development), an essential component of Polycomb repressive complex 2 (PRC2), involved in transcriptional repression through methylation of histone H3K27. A-395N is structurally similar, but exhibits no activity in the biochemical and cellular assays, so is an ideal control compound. For characterization details of the active probe, A-395, please visit the A-395 probe summary on the Structural Genomics Consortium (SGC) website.
A-395, the active enantiomer, is available from Sigma. To learn more about and purchase A-395, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
A-395, the active enantiomer, is available from Sigma. To learn more about and purchase A-395, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
特點和優勢
A-395N is a negative control for A-395, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Mélanie Criqui et al.
eLife, 9 (2020-04-17)
The precise relationship between epigenetic alterations and telomere dysfunction is still an extant question. Previously, we showed that eroded telomeres lead to differentiation instability in murine embryonic stem cells (mESCs) via DNA hypomethylation at pluripotency-factor promoters. Here, we uncovered that
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