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Merck

SML1779

Sigma-Aldrich

Nigericin sodium salt

from Streptomyces hygroscopicus, ≥98% (HPLC), solution, polyether ionophore

别名:

3B2-6379, HE331800, Helex C, 抗生素K178, 抗生素X464, 聚醚A, 钠; 2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2- [5-[(3S,5R)-5-[(2S,3S,5R,6R)- 6-羟基-6-(羟甲基)-3,5-二甲基恶烷-2-基] -3-甲基氧杂戊-2-基] -5-甲基氧杂草-2-基] -7-甲氧基-2,4,6-三甲基-1,10-二氧杂螺环[4.5]癸烷-9-基]甲基] -3-甲基恶烷-2-基]丙酸酯, 阿扎霉素M

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About This Item

经验公式(希尔记法):
C40H67NaO11
CAS号:
分子量:
746.94
UNSPSC代码:
12352200
NACRES:
NA.77

产品名称

尼日利亚菌素钠盐成品溶液, 5 mg/mL (DMSO:ethanol 1:1)

生物来源

Streptomyces hygroscopicus

质量水平

表单

solution

浓度

5 mg/mL (DMSO:ethanol 1:1)

抗生素抗菌谱

Gram-positive bacteria

作用机制

cell membrane | interferes

运输

ambient

储存温度

2-8°C

SMILES字符串

[Na+].[O-]C(=O)C(C1O[C@H](CC[C@@H]1C)C[C@H]2O[C@]3(OC(CC3C)(C4OC(CC4)(C5O[C@H](C[C@@H]5C)[C@H]6O[C@@]([C@@H](C[C@@H]6C)C)(O)CO)C)C)[C@@H]([C@@H](C2)OC)C)C

InChI

1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1

InChI key

MOYOTUKECQMGHE-KKCUGXASSA-M

生化/生理作用

尼日利亚菌素是一种聚醚离子载体,可催化碱金属(K+)与 H+(反位)的电子中性交换。
尼日利亚菌素是一种聚醚离子载体,可催化碱金属(K+)与 H+(反位)的电子中性交换。 尼日利亚菌素跨膜转运单价阳离子具有以下特异性:K+ >Rb+ >Cs+ >>Na+,从而破坏膜电位并刺激线粒体中的 ATPase 活性。
尼日利亚菌素通过促进离子跨膜扩散来杀死细菌。
低浓度(0.5 μM)的尼日利亚菌素会迅速降低 pHi,导致在大脑微血管内皮细胞中刺激 PG 产生 1.5 到 2 倍,并阻止 Erlich 腹水癌细胞中 DNA 的合成。 在脊髓灰质炎病毒进入 Hela 细胞后,用尼日利亚菌素处理可防止脊髓灰质炎病毒对宿主蛋白合成的抑制。 尼日利亚菌素还广泛用于研究可变系统中膜电位变化的后果。

制备说明

以 6.7 mM 的浓度提供尼日利亚菌素钠盐制备的溶液。 可用所需溶剂将该溶液进一步稀释至工作浓度(0.5-10 μM)。
该产品为5mg /mL溶液,DMSO和乙醇按1:1混合配制。

储存及稳定性

该产品可在2-8°C下保存,建议每4年重新检测一次。该溶液在冷藏条件下相当稳定,无需冷冻。

象形图

Flame

警示用语:

Warning

危险声明

危险分类

Flam. Liq. 3

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

78.8 °F

闪点(°C)

26 °C


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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G D Eytan et al.
The Journal of biological chemistry, 265(22), 12949-12954 (1990-08-05)
Reconstituted transhydrogenase-ATPase vesicles obtained with purified beef heart transhydrogenase and oligomycin-sensitive ATPase were investigated with respect to the mode of interaction between the two proton pumps, with special reference to the relative contributions of the membrane potential and proton gradient
A A Guffanti et al.
Journal of general microbiology, 114(1), 201-206 (1979-09-01)
At an external pH of 3.5, nigericin (which catalyses an electroneutral H+/K+ exchange) abolished the transmembrane proton gradient (delta pH) of Bacillus acidocaldarius, causing a rapid acidification of the cytoplasm from approximately pH 6.0 to pH 3.5. A pronounced loss
Hachiro Konaka et al.
The EMBO journal, 42(20), e112573-e112573 (2023-09-04)
Mitochondrial DNA (mtDNA) leakage into the cytoplasm can occur when cells are exposed to noxious stimuli. Specific sensors recognize cytoplasmic mtDNA to promote cytokine production. Cytoplasmic mtDNA can also be secreted extracellularly, leading to sterile inflammation. However, the mode of
Mayu Sugiyama et al.
Biochimica et biophysica acta, 1660(1-2), 24-30 (2004-02-06)
A novel gene transfer system utilizing polycation liposomes (PCLs), obtained by modifying liposomes with cetyl polyethylenimine (PEI), was previously developed (Gene Ther. 7 (2002) 1148). PCLs show notable transfection efficiency with low cytotoxicity. However, the mechanism of PCL-mediated gene transfer
L B Margolis et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(17), 6626-6629 (1989-09-01)
Acidification of the cytoplasm of Ehrlich ascites carcinoma cells to pH 6.3 arrests DNA synthesis in these cells. Such an effect can be achieved by incubating the cells at pH 6.2 or by adding low concentrations of the K+/H+ antiporter

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