SML1775

K-756

≥98% (HPLC)

• 别名: 3-[[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]methyl]-3,4-dihydro-2(1H)-quinazolinone
• 经验公式（希尔记法）: C₂₄H₂₇N₅O₃
• CAS号: 130017-40-2
• 分子量: 433.50
• UNSPSC代码: 12352200

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to beige
• 溶解性: DMSO: 5 mg/mL, clear (warmed)
• 储存温度: 2-8°C
• SMILES字符串: O=C1NC2=C(C=CC=C2)CN1CC3CCN(C4=C(C=C(OC)C(OC)=C5)C5=NC=N4)CC3

说明

生化/生理作用

K-756 is an orally available, potent and selective tankyrase inhibitor, which binds to the induced-pocket of tankyrase. K-756 is a selective Wnt/β-catenin pathway inhibitor that stabilizes Axin and reduces active β-catenin. K-756 inhibits the proliferation of APC mutant colorectal cancer COLO 320DM and SW403 cell lines.

K-756 is an orally available, potent and selective tankyrase inhibitor.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable