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品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to beige
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
2-8°C
InChI
1S/C22H18FN3O2.ClH/c1-14-9-18(23)20(11-21(14)27)26-22-17-8-7-16(10-19(17)24-13-25-22)28-12-15-5-3-2-4-6-15;/h2-11,13,27H,12H2,1H3,(H,24,25,26);1H
InChI 密鑰
AVRHWGLIYGJSOD-UHFFFAOYSA-N
生化／生理作用
ZM323881 is a selective inhibitor of VEGFR-2 with an IC50 value of 2 nM. ZM323881 is selective for VEGFR-2 over VEGFR-1 and other receptor tyrosine kinases including PDGFRβ, FGFR1, EGFR and erbB2. ZM323881 inhibited VEGF-A-induced endothelial cell proliferation with an IC50 value of 8 nM.
ZM323881 is also known as (5‐{[7‐(benzyloxy) quinazolin‐4‐yl]amino}‐4‐fluoro‐2‐methylphenol). It is capable of blocking the efflux function and altering breast cancer resistant protein (BCRP)-related multidrug resistance (MDR).
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
C E Whittles et al.
Microcirculation (New York, N.Y. : 1994), 9(6), 513-522 (2002-12-17)
Vascular endothelial growth factor (VEGF) increases vascular permeability and angiogenesis in many pathological conditions including cancer, arthritis, and diabetes. VEGF activates VEGF-Receptor 1(VEGF-R1) and VEGF-Receptor 2 (VEGF-R2), which autophosphorylate to initiate a signaling cascade resulting in angiogenesis and increased microvascular
Selective reversal of BCRP-mediated MDR by VEGFR-2 inhibitor ZM323881
Zhang Yun-Kai, et al.
Biochemical Pharmacology, 132, 29-37 (2017)
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