SML0833

HLY78

≥98% (HPLC)

• 别名: 4-Ethyl-5,6-Dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine, 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
• 经验公式（希尔记法）: C₁₇H₁₇NO₂
• CAS号: 854847-61-3
• 分子量: 267.32
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to beige
• 溶解性: DMSO: 5 mg/mL, clear (warmed)
• 储存温度: 2-8°C

说明

生化/生理作用

Activator of the Wnt/β-Catenin signaling pathway.

HLY78 is an activator of the Wnt/β-Catenin signaling pathway. HLY78 acts upstream of β-catenin synergistically with Wnt. It is believed to bind at a cavity at the dimeric interface of the Axin DIX domain, causing a conformational change of Axin to an active state, potentiating Axin–LRP6 association and promoting Wnt signaling transduction. There are several Wnt inhibitors used to study their potential in cancer therapy but few small molecules that activate the Wnt pathway. In Zebrafish, HLY78 increased the expression of the hematopoietic stem cell (HSC) transcription factors runx1 and cmyb, showing that it might be useful in HSC expansion, which could be important in transplantation and recovery after injury.

安全信息

• 象形图: GHS09
• 警示用语：: Warning
• 危险声明: H410
• 预防措施声明: P273 - P391 - P501
• 危险分类: Aquatic Acute 1 - Aquatic Chronic 1
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable