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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
FC(F)(F)c1ccc(cc1)N2CCN(CC2)CC[n]3c4c([nH][c]3=O)cccc4
InChI
1S/C20H21F3N4O/c21-20(22,23)15-5-7-16(8-6-15)26-12-9-25(10-13-26)11-14-27-18-4-2-1-3-17(18)24-19(27)28/h1-8H,9-14H2,(H,24,28)
InChI key
CCIZQGRSEAHATK-UHFFFAOYSA-N
生化/生理作用
氟班色林是 5-HT1A 受体激动剂和 5-HT2A 受体拮抗剂。
氟班色林是 5-HT1A 受体激动剂和 5-HT2A 受体拮抗剂。氟班色林对人 5-HT1A受体 (Ki = 1 nm) 具有高亲和力，对 5-HT2A (Ki = 49 nm) 和 D4 (Ki = 4–24 nm) 受体亲和力较低，对多种其他神经递质受体和离子通道的亲和力可忽略不计。氟班色林被用作女性绝经前性欲减退 (HSDD) 的一种新型非激素治疗方法。氟班色林。最近，在帕金森氏病模型中发现氟班色林可减轻 L-DOPA 引起的运动障碍。
特点和优势
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
John Thorp et al.
The journal of sexual medicine, 9(3), 793-804 (2012-01-14)
Hypoactive Sexual Desire Disorder (HSDD) is characterized by low sexual desire that causes marked distress or interpersonal difficulty. To assess the efficacy and tolerability of flibanserin, a postsynaptic 5-HT1A agonist/5-HT2A antagonist, in the treatment of premenopausal women with HSDD. North
Dysfunctional women remain unsexed.
Michael G Wyllie
BJU international, 106(3), 431-432 (2010-07-27)
Drug for low sexual desire carries significant harms, FDA advisers find.
Ray Moynihan
BMJ (Clinical research ed.), 341, c3339-c3339 (2010-07-09)
Boehringer Ingelheim withdraws libido drug for women.
Jeanne Lenzer
BMJ (Clinical research ed.), 341, c5701-c5701 (2010-10-14)
Leonard R Derogatis et al.
The journal of sexual medicine, 9(4), 1074-1085 (2012-01-18)
Hypoactive sexual desire disorder (HSDD) is the most common form of female sexual dysfunction and is characterized by low sexual desire that causes distress. The aim of this study was to assess the efficacy and safety of flibanserin, a postsynaptic
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