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Merck
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文件

M1323

Sigma-Aldrich

Midostaurin hydrate

≥98% (HPLC), solid, kinase inhibitor

别名:

CGP 41251, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide, N-benzoylstaurosporine, PKC-412

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About This Item

经验公式（希尔记法）:
C35H30N4O4 · xH2O
CAS号:
1217450-80-0
分子量:
570.64 (anhydrous basis)
MDL號碼:
MFCD12828879
分類程式碼代碼:
12352200
PubChem物質ID:
329817870
NACRES:
NA.77

product name

Midostaurin hydrate, ≥98% (HPLC), solid

化驗

≥98% (HPLC)

形狀

solid

顏色

off-white

溶解度

DMSO: >10 mg/mL

儲存溫度

−20°C

SMILES 字串

O.CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)[n@@H]3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8[n@H]2c7c35)N(C)C(=O)c9ccccc9

InChI

1S/C35H30N4O4.H2O/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38;/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40);1H2/t25-,26-,32-,35+;/m1./s1

InChI 密鑰

YEKDLUZCCDJYAJ-LJAYRLSQSA-N

生化／生理作用

Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF. Midostaurin inhibits cell growth and phosphorylation of FLT3, STAT5, and ERK. Midostaurin is a potent inhibitor of a spectrum of FLT3 activation loop mutations.

特點和優勢

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H360FD

危險分類

Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Mahmoud Hallal et al.
BMC cancer, 21(1), 789-789 (2021-07-10)
Despite the introduction of targeted therapies, most patients with myeloid malignancies will not be cured and progress. Genomics is useful to elucidate the mutational landscape but remains limited in the prediction of therapeutic outcome and identification of targets for resistance.
Edmund H Wilkes et al.
Molecular & cellular proteomics : MCP, 16(9), 1694-1704 (2017-07-05)
Cell survival is regulated by a signaling network driven by the activity of protein kinases; however, determining the contribution that each kinase in the network makes to such regulation remains challenging. Here, we report a computational approach that uses mass
Jin Kawata et al.
Blood cells, molecules & diseases, 54(2), 206-209 (2014-12-04)
Monocytes and neutrophils are activated during disseminated intravascular coagulation. Tissue factor, the main initiator of coagulation, is expressed by monocytes, while elastase is released by neutrophils. This study investigated tissue factor production by peripheral monocytes after stimulation with human neutrophil
Ee Lin Wong et al.
Nature communications, 10(1), 66-66 (2019-01-10)
Protein-templated fragment ligations have been established as a powerful method for the assembly and detection of optimized protein ligands. Initially developed for reversible ligations, the method has been expanded to irreversible reactions enabling the formation of super-additive fragment combinations. Here
Ikuko Omori et al.
Experimental hematology, 52, 56-64 (2017-05-17)
In core-binding factor acute myeloid leukemia (CBF-AML), there have been conflicting reports regarding the status as an unfavorable prognostic factor of mutation in the KIT gene, the significance of which remains unclear. We previously reported that prognoses differ between the
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Protein Kinase C (PKC)

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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