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Merck
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文件

SML0773

Sigma-Aldrich

GSK-650394

≥98% (HPLC)

别名:

2-环戊基-4-(5-苯基-1H-吡咯并[2,3-B]吡啶-3-基)苯甲酸, GSK 650394, GSK650394

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About This Item

经验公式（希尔记法）:
C25H22N2O2
CAS号:
890842-28-1
分子量:
382.45
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

room temp

InChI

1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)

InChI 密鑰

WVSBGSNVCDAMCF-UHFFFAOYSA-N

應用

GSK-650394已被用作血清和糖皮质激素激活激酶（SGK1）抑制剂。

生化／生理作用

GSK-650394对血清和糖皮质激素激活激酶1（SGK1）的 IC50 值为62 nM ，对SGK2的IC50值为103 nM。 它能够在对细胞无毒的浓度下阻止病毒复制。
GSK-650394是一种有效的选择性血清和糖皮质激素调节激酶1（SGK1）拮抗剂。

特點和優勢

《受体分类和信号转导》手册的 PKB/Akt 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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W Bruce Sneddon et al.
The Journal of biological chemistry, 291(36), 18632-18642 (2016-07-20)
Parathyroid hormone (PTH) and FGF23 are the primary hormones regulating acute phosphate homeostasis. Human renal proximal tubule cells (RPTECs) were used to characterize the mechanism and signaling pathways of PTH and FGF23 on phosphate transport and the role of the
Judith G Alamares-Sapuay et al.
Journal of virology, 87(10), 6020-6026 (2013-03-15)
We previously performed a small interfering RNA (siRNA) screen and identified serum- and glucocorticoid-regulated kinase 1 (SGK1) as a host factor required for influenza A virus replication. However, the role of SGK1 in the influenza viral life cycle has never
Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport.
Sneddon WB
The Journal of Biological Chemistry, 291(36), 18632-18642 (2016)
Ferran Medina-Jover et al.
FEBS letters, 594(19), 3200-3215 (2020-08-09)
BMP9 is a cytokine involved in the maturation phase of the angiogenic process that signals through its serine/threonine receptor ALK1 and its coreceptor endoglin. In this paper, we explain how BMP9 directs the regulation of endothelial cell proliferation blockage while

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