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Merck
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文件

SML0602

Sigma-Aldrich

Propiverine hydrochloride

≥98% (HPLC)

别名:

α,α-Diphenyl-α-propoxyacetic acid hydrochloride 1-methyl-4-piperidyl ester, α-Phenyl-α-propoxybenzeneacetic acid 1-methyl-4-piperidinyl ester hydrochloride, (1-Methylpiperidin-1-ium-4-yl) 2,2-diphenyl-2-propoxyacetate chloride, 1-Methyl-4-piperidyl diphenylpropoxyacetate hydrochloride

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About This Item

经验公式（希尔记法）:
C23H29NO3 · HCl
CAS号:
54556-98-8
分子量:
403.94
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 5 mg/mL, clear (warmed)

儲存溫度

2-8°C

InChI

1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H

InChI 密鑰

KFUJMHHNLGCTIJ-UHFFFAOYSA-N

一般說明

Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours.

生化／生理作用

Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.

特點和優勢

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形圖

CorrosionExclamation mark
GHS05,GHS07

訊號詞

Danger

危險聲明

H315,H318,H335

危險分類

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Editorial comment from Dr Sekido to propiverine hydrochloride in Japanese patients with overactive bladder: a randomized, double-blind, placebo-controlled trial.
Noritoshi Sekido
International journal of urology : official journal of the Japanese Urological Association, 18(5), 373-374 (2011-03-09)
Tetsuo Ogata et al.
Chemical & pharmaceutical bulletin, 60(8), 976-984 (2012-08-07)
The aim of the present study was to mask the bitterness of propiverine hydrochloride (P-4) by converting it to propiverine free base. Fine granules comprising the free base, which was converted from P-4 by desalination, were prepared. By using Fourier
Heinrich Schulte-Baukloh et al.
Journal of pediatric urology, 8(4), 386-392 (2011-09-13)
To evaluate prospectively the efficacy and tolerability of propiverine for long-term treatment of neurogenic detrusor overactivity (NDO) in children. 17 children and adolescents with NDO (10 female, 7 male; average age at last consultation 13.0 years) were evaluated during long-term
F Donath et al.
International journal of clinical pharmacology and therapeutics, 49(6), 353-365 (2011-05-27)
Two comprehensively designed mono-centric ECG studies were performed to investigate the influence of propiverine hydrochloride and its main metabolite propiverine-N-oxide on cardiac function with regard to QTc prolongation, QTc dispersion and T-wave shape. The first study was conducted on 24
Momokazu Gotoh et al.
Urology, 78(4), 768-773 (2011-08-23)
To assess the responsiveness and minimal clinically important change (MCIC) in the Overactive Bladder Symptom Score (OABSS), a single score used to quantify overactive bladder symptoms. The data were derived from a clinical trial of propiverine in patients with overactive
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Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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