SML0565

MK-0343

≥98% (HPLC)

• 别名: 7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine, MRK-409
• 经验公式（希尔记法）: C₁₉H₁₇F₂N₇O
• CAS号: 233275-76-8
• 分子量: 397.38
• MDL编号: MFCD22683821
• UNSPSC代码: 12352202
• PubChem化学物质编号: 329825556
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to beige
• 溶解性: DMSO: 10 mg/mL, clear
• 储存温度: 2-8°C
• SMILES字符串: Cn1ncnc1COc2nn3c(nnc3cc2C4CCC4)-c5c(F)cccc5F
• InChI: 1S/C19H17F2N7O/c1-27-16(22-10-23-27)9-29-19-12(11-4-2-5-11)8-15-24-25-18(28(15)26-19)17-13(20)6-3-7-14(17)21/h3,6-8,10-11H,2,4-5,9H2,1H3
• InChI key: GOIFCXRIFSYPFG-UHFFFAOYSA-N

说明

生化/生理作用

MK-0343 (MRK-409) is a partial agonist for GABAA receptors with comparable Ki values for α1, α2, α3 and α5 containing receptors (0.2 – 0.4 nM). The compound has the greatest agonist activity against α3 receptors, and is brain penatrant, and displays anxiolytic activity in rodent and primate models.

MK-0343 is a GABAA partial agonist.

特点和优势

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable