推荐产品
生物源
Verticillium hemipterigenum
化驗
≥98% (HPLC)
溶解度
DMSO: soluble
H2O: insoluble
chloroform: soluble
ethyl acetate: soluble
methanol: soluble
抗生素活性譜
viruses
作用方式
enzyme | inhibits
儲存溫度
−20°C
InChI
1S/C23H29ClO4/c1-13(10-11-23(5)14(2)7-9-19(26)16(23)4)6-8-17-21(27)18(12-25)15(3)20(24)22(17)28/h6,10-12,14,16,27-28H,7-9H2,1-5H3/b11-10+,13-6+
InChI 密鑰
SETVRSKZJJWOPA-OGCXVWDESA-N
應用
The effect of Ascochlorin on MMP-9 was compared with that of Silibinin in MCF-7 human breast carcinoma cells.
生化／生理作用
Ascochlorin is a prenyl-phenol compound and a dihydroorotate dehydrogenase (DHODH) inhibitor. It has hypolipidemic functionality and suppresses hypertension as well as immune responses. It is a glycoside, which also elicits inhibition of the respiratory chain cytochrome bc1.
Ascochlorin is an isoprenoid antibiotic produced by Verticillium hemipterigenum, initially identified as an antiviral and antitumor agent. Research also indicates that ascochlorin inhibits the Qi and Qo quinone binding sites of the mitochondria cytochrom bc1 complex. Moreover, ascochlorin activates p53, probably as a result of its inhibitory effect on mitochondrial respiration. In addition, ascochlorin has the ability to suppress the nuclear subscription enzyme protein-1, a nuclear transcription factor activator, which leads to suppression of the extra-cellular enzyme, matrix metalloproteinase-9 (MMP9). The regulation of MMP is implicated in renal development, macrophage differentiation, atherosclerosis, inflammation, rheumatoid arthritis, and tumor invasion. Ascochlorin was also found to be effective against Mx-1, an estrogen lacking breast cancer cell line.
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Wenbin Shen et al.
European journal of pharmacology, 791, 205-212 (2016-10-30)
Human dihydroorotate dehydrogenase (hDHODH) is an inner mitochondrial membrane enzyme that involves in the fourth step of the biosynthesis of pyrimidine base. Inhibitors of hDHODH have been proven efficacy for the treatments of inflammation, rheumatoid arthritis, multiple sclerosis and cancer.
Edward A Berry et al.
Biochimica et biophysica acta, 1797(3), 360-370 (2009-12-23)
Ascochlorin is an isoprenoid antibiotic that is produced by the phytopathogenic fungus Ascochyta viciae. Similar to ascofuranone, which specifically inhibits trypanosome alternative oxidase by acting at the ubiquinol binding domain, ascochlorin is also structurally related to ubiquinol. When added to
Syng-Ook Lee et al.
Biochemical and biophysical research communications, 354(1), 165-171 (2007-01-12)
Matrix metalloproteinase-9 (MMP-9) plays an important role in the invasion and metastasis of cancer cells. In this study, we examined the inhibitory effect of silibinin, a flavonoid antioxidant from milk thistle (Silybum marianum L.) on PMA-induced MMP-9 expression in MCF-7
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门