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About This Item
经验公式（希尔记法）:
C22H20N4
CAS号:
分子量:
340.42
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: ≥20 mg/mL
儲存溫度
room temp
SMILES 字串
C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4
InChI
1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
InChI 密鑰
QAIMUUJJAJBPCL-UHFFFAOYSA-N
應用
用DBeQ处理HeLa细胞，并通过活细胞成像对该处理对细胞 体内 泛素化和蛋白质脱位的影响进行了研究。
生化／生理作用
DBeQ是ATP酶p97的有效和特异性抑制剂，ATP酶是泛素-融合降解（UFD）途径的组成部分。DBeQ可抑制泛素化蛋白质的降解、内质网相关的降解途径、以及自噬体成熟。该化合物还可有效抑制细胞增殖并诱导胱天蛋白酶3/7的活性和细胞凋亡。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
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