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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
yellow
溶解性
DMSO: ≥25 mg/mL
储存温度
2-8°C
SMILES字符串
Cc1ccccc1N2C(=S)S\C(=C\C=C\c3ccccc3)C2=O
InChI
1S/C19H15NOS2/c1-14-8-5-6-12-16(14)20-18(21)17(23-19(20)22)13-7-11-15-9-3-2-4-10-15/h2-13H,1H3/b11-7+,17-13+
InChI key
UYZLENPCNZVWQZ-QHMSGILQSA-N
应用
IMB-10 may be used to study integrin-mediated signaling in tumor cells.
生化/生理作用
IMB-10 is a ligand for the αMβ2 integrin that stabilizes the binding of the integrin to endogenous ligands such as proMMP-9 and fibrinogen. IMB-10 blocks migration of lymphocyte cell lines and inhibits leukocyte infiltration in a murine thioglycolate-induced peritonitis.
IMB-10 is a thioxothiazolidine compound that inhibits the infiltration of leukocytes to the site of tumor and blocks the invasion of HSC-3 carcinoma. It modulates the host inflammatory responses and tumor progression.
Stabilizing Ligand of αMβ2 integrin
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Juho Suojanen et al.
Anticancer research, 27(6B), 3775-3781 (2008-01-30)
Leukocyte immunomodulation has great clinical potential as a therapy of inflammatory conditions and cancer. We have recently developed leukocyte alphaMbeta2 integrin targeting small molecule (IMB-10) capable of inhibiting leukocyte migration and recruitment in vitro and in vivo. The purpose of
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