SMB01068

Licoricidin

≥90% (LC/MS-ELSD)

• 别名: (+)-Licoricidin, 7-O-Demethyllicorisoflavan A, Licorisoflavan B
• 经验公式（希尔记法）: C₂₆H₃₂O₅
• CAS号: 30508-27-1
• 分子量: 424.53
• MDL编号: MFCD32182601
• UNSPSC代码: 12352205
• NACRES: NA.25

属性

• 生物来源: plant
• 方案: ≥90% (LC/MS-ELSD)
• 表单: solid
• 分子量: 424.53
• 应用: metabolomics; vitamins, nutraceuticals, and natural products
• 储存温度: −20°C
• SMILES字符串: O1C[C@H](Cc3c1cc(c(c3OC)CC=C(C)C)O)c2c(c(c(cc2)O)CC=C(C)C)O
• InChI: 1S/C26H32O5/c1-15(2)6-8-19-22(27)11-10-18(25(19)29)17-12-21-24(31-14-17)13-23(28)20(26(21)30-5)9-7-16(3)4/h6-7,10-11,13,17,27-29H,8-9,12,14H2,1-5H3/t17-/m0/s1
• InChI key: GBRZTUJCDFSIHM-KRWDZBQOSA-N

说明

一般描述

Licoricidin, also known as Licorisoflavan B, a hydroxyisoflavan and an aromatic ether, is a bioactive natural compound commonly derived from Glycyrrhiza Sp. (G. uralensis, G. inflata, and G. aspera) plants. Current research indicates that this metabolite is an inhibitor and may possess diverse biological activities, including anti-inflammatory, antitumor, antibacterial, antiangiogenic and antimetastatic properties.

应用

Licoricidin is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

生化/生理作用

Licoricidin is a potent anti-metastatic agent, effectively reducing the metastatic and invasive capabilities of malignant prostate cancer cells. Additionally, both Licoricidin and Licorisoflavan A exhibit strong antibacterial properties against Porphyromonas gingivalis, Prevotella intermedia, and Solobacterium moorei, with minimal inhibitory concentrations ranging from 2 to 80 µg/ml. These compounds have the potential to mitigate bacterial volatile sulfur compound (VSC) production, making them suitable for managing halitosis. Furthermore, they hold promise for novel approaches to modulate hosts′ responses in conditions involving cytokines and MMPs, such as periodontitis. Licoricidin may find application in topically applied anti-aging formulations by preventing UVA-induced photoaging through ROS scavenging, ultimately limiting MMP-1 activity.

特点和优势

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

其他说明

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安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable