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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 43 kDa
物種活性
mouse, human, rat
濃度
~1 mg/mL
技術
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TP53(7157)
一般說明
Anti-p53 Antibody detects endogenous levels of total p53 protein.
TP53 gene is mapped to human chromosome 17p13.1.
免疫原
The antiserum was produced against synthesized peptide derived from human p53.
Immunogen Range: 283-332
Immunogen Range: 283-332
生化／生理作用
TP53 gene is involved in the regulation of cell cycle, senescence and apoptosis upon oncogene activation, stress and DNA damage. Therefore, the gene has anti-tumor activity initiation and prevents tumor progression. Mutation in TP53 is known to be the major cause of almost half of all human malignancy. Breast cancer is one such condition in which, the disease development is severe due to mutation in TP53 gene.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting
Fountzilas
Oncotarget, 7(22), 32731?3275-32731?3275 (2016)
Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity
Sriraman A
Oncotarget, 7(22), 31623?31638-31623?31638 (2016)
Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy
Ridinger MS
PLoS ONE, 12(12), 1-22 (2017)
Wip1 phosphatase: between p53 and MAPK kinases pathways
Goloudina, AR
Oncotarget, 7(21), 31563?31571-31563?31571 (2016)
Peiyu Xie et al.
International journal of oncology, 52(5), 1380-1390 (2018-03-08)
Cancer has long been one of the most malignant diseases worldwide. Processes in cancer cells are often mediated by Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (p38 MAPK) and other signaling pathways. Traditional therapies are often problematic. Recently, a novel
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p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.
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