SAB4300488

抗-FGFR1 (Ab-154) 兔抗

affinity isolated antibody

• 别名: Anti-BFGFR antibody produced in rabbit, Anti-CD331 antibody produced in rabbit, Anti-CEK antibody produced in rabbit, Anti-FGFBR antibody produced in rabbit, Anti-fibroblast growth factor receptor 1 antibody produced in rabbit
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 分子量: ~145 kDa
• 种属反应性: human, mouse
• 浓度: 1 mg/mL
• 技术: western blot: 1:500-1:1000
• 同位素/亚型: IgG
• 免疫原序列: (A-P-Y-W-T)
• NCBI登记号: NP_001167534.1
• UniProt登记号: P11362
• 运输: wet ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... FGFR1(2260)

说明

一般描述

FGFR1 (fibroblast growth factor receptor 1) gene codes for 9 isoforms of FGFR1. It has 19 exons spanning 55kb DNA. It is located on human chromosome 8p11.1. High level expression of FGFR1 is seen in midfacial membranous ossification sites. It is mostly present in neurons like hippocampal and dentate gyrus neurons.

免疫原

Peptide sequence around aa. 152-156 (A-P-Y-W-T), according to the protein FGFR1.

应用

Anti-FGFR1 (Ab-154) antibody has been used in western blotting .

生化/生理作用

FGFR1 (fibroblast growth factor receptor 1) helps in the growth of nervous system. It also controls the skeletal development and bone homeostasis. FGFR1 mutations lead to craniosynostosis and facial abnormalities. Mutation in FGFR1 Ig-like domain II-III linker region (FGFR1 P252R) results in Pfeiffer syndrome.

特点和优势

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目标描述

FGF encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable