SAB4200468
Anti-JAM-A antibody, Mouse monoclonal
clone J10.4, purified from hybridoma cell culture
别名:
Monoclonal Anti-CD321, Monoclonal Anti-F11 receptor, Monoclonal Anti-F11R, Monoclonal Anti-JAM, Monoclonal Anti-JAM1, Monoclonal Anti-JAMA, Monoclonal Anti-JCAM, Monoclonal Anti-KAT, Monoclonal Anti-PAM-1
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所有图片(3)
About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
推荐产品
生物源
mouse
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
J10.4, monoclonal
形狀
buffered aqueous solution
分子量
antigen 37 kDa
物種活性
human
濃度
~1.0 mg/mL
技術
immunoblotting: 1.0-2.0 μg/mL using HepG2 or A431 or A549 total cell extracts
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... F11R(50848)
一般說明
Anti-JAM-A antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the hybridoma J10.4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant human JAM. Junctional adhesion molecule A (JAM-A) is expressed at tight junctions of endothelial and epithelial cells as well as on a variety of hematopoietic cells. It belongs to the transmembrane IgG glycoprotein family and is also expressed in monocytes, lymphocytes, neutrophils, dendritic cells, platelets, and spermatozoa. The JAM-A or F11R gene is mapped to human chromosome 1q23.3.
特異性
Anti-JAM-A antibody, Mouse monoclonal recognizes human JAM-A.
免疫原
derived from the hybridoma J10.4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant human JAM fusion protein.
應用
Anti-JAM-A antibody, Mouse monoclonal has been used in:
- western blotting
- staining for confocal microscopy
- immunoprecipitation
- immunocytochemistry
- flow cytometry
生化／生理作用
Junctional adhesion molecule A(JAM-A) function has been linked with regulation of cell migration/invasion, platelet adhesion, cell polarity, cell proliferation, and epithelial or endothelial barrier function. However, the mechanisms by which JAM-A mediates these processes have not been well elucidated. JAM-A functional significance is connected with inflammation, angiogenesis, hypertension, ischemia/reperfusion, and atherosclerosis. JAM-A has also been linked to breast, endometrial, renal cell carcinomas and gastric cancer.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
儲存和穩定性
For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Hisato Koshiba et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 19(2), 208-213 (2009-04-28)
Junctional adhesion molecule A (JAM-A) is involved in cell-cell contact and tight junction formation. Loss of cell adhesion molecules may be associated with high histologic grade and invasiveness of endometrial carcinoma. We attempted to determine JAM-A expression in human endometrial
Stefania Vetrano et al.
Annals of the New York Academy of Sciences, 1165, 308-313 (2009-06-23)
Tight junctions (TJ) are junctional proteins whose function is to maintain an intact intestinal epithelial barrier and regulate the paracellular movement of water and solutes. Altered TJ structure and epithelial permeability are observed in inflammatory bowel disease and seem to
Tim Steinbacher et al.
Cellular and molecular life sciences : CMLS, 75(8), 1393-1409 (2017-12-15)
Cell adhesion molecules (CAMs) of the immunoglobulin superfamily (IgSF) regulate important processes such as cell proliferation, differentiation and morphogenesis. This activity is primarily due to their ability to initiate intracellular signaling cascades at cell-cell contact sites. Junctional adhesion molecule-A (JAM-A)
Paul Gutwein et al.
Biochemical and biophysical research communications, 380(2), 387-391 (2009-03-03)
Junctional adhesion molecule-A (JAM-A) is one component of tight junctions which are involved in important processes like paracellular permeability, cell polarity, adhesion, migration, and angiogenesis. Here we describe JAM-A expression in distal convoluted tubule, connecting tubule, and in cells of
Association of rs61803665 Polymorphism in the F11R Gene with Increased Risk of Gastric Cancer
Khalili Z, et al.
Asian Pacific Journal of Cancer Biology, 4(1), 15-18 (2019)
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