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Merck

SAB4200023

Sigma-Aldrich

Anti-VPS4B antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

Anti-SKD1, Anti-SKD1-homolog, Anti-SKD1A, Anti-SKD2, Anti-VPS4, Anti-VPS4-1, Anti-Vacuolar protein sorting 4 homolog A, Anti-Vacuolar protein sorting factor 4A

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen ~50 kDa

物種活性

human, mouse

濃度

~1.0 mg/mL

技術

immunoprecipitation (IP): 10-20 μg using lysate of mouse 3T3 cells
western blot: 2-4 μg/mL using whole extracts of G361 cells

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... VPS4B(9525)

相关类别

一般說明

Vacuolar protein sorting 4 homolog B (Vps4B) is a member of the AAA protein family (ATPases associated with diverse cellular activities) and is a homolog of yeast Vps4 protein. In humans, two of yeast protein paralogs have been identified as Vps4A and Vps4B. Both share high degree of amino acid sequence. The gene for Vps4B resides on human chromosome 18.

應用

Anti-VPS4B antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

生化/生理作用

Vacuolar protein sorting 4 (Vps4) mediates endosomal membrane protein sorting, retroviral budding, and cytokinesis by recognizing membrane-associated endosomal sorting complexes required for transport (ESCRT-III) assemblies and catalysing their disassembly.

外觀

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Comparative sequence and expression analyses of four mammalian VPS4 genes
Beyer A, et al.
Gene, 305(1), 47-59 (2003)
Luana L Scheffer et al.
Nature communications, 5, 5646-5646 (2014-12-24)
In muscle and other mechanically active tissue, cell membranes are constantly injured, and their repair depends on the injury-induced increase in cytosolic calcium. Here, we show that injury-triggered Ca(2+) increase results in assembly of ESCRT III and accessory proteins at
Membrane scission by the ESCRT-III complex
Wollert T, et al.
Nature, 458(7235), 172-172 (2009)

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