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生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 100 kDa
物種活性
rat
技術
microarray: suitable
western blot: 1:3,000 using cytosolic S1 fraction of rat brain
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... SYNPO(11346)
rat ... Synpo(60324)
一般說明
Synaptopodin is a proline-rich, actin-associated protein (100 kDa) is present in the post-synaptic density (PSD) in actin cytoskeleton. It is also present in the dendritic spines and differentiated podocytes. Synaptopodin contains a high amount of proline residues (~20%), which are evenly distributed along the protein sequence, thus virtually excluding the formation of globular domains. In particular, synaptopodin does not contain functional domains found in receptor clustering PSD proteins. Sequence comparison between human and mouse synaptopodin shows 84% identity. The exclusive site of synaptopodin expression in the telencephalon is restricted to specific areas of high synaptic plasticity, i.e. in the perykaria of the olfactory bulb, striatum, and hippocampus.
免疫原
synthetic peptide corresponding to amino acids 184-202 of rat synaptopodin conjugated to KLH. This rat synaptopodin sequence has ~70% identity with human synaptopodin.
應用
Anti-Synaptopodin (SE-19) antibody produced in rabbit has been used in:
- immunofluorescence microscopy
- immunohistochemistry
- western blotting
生化／生理作用
Synaptopodin is thought to play an important role in synaptic plasticity and is associated in the modulation of motility of actin in neuronal dendritic spines. The association of synaptopodin with the specialized actin system of renal podocyte foot processes suggests that it may play a role in actin cytoskeleton dynamics of these cellular extensions. Synaptopodin has been found to interact with α-actinin-4 and the tight junction protein Membrane-associated guanylate kinase inverted 1 (MAGI-1) in Madin-Darby Canine Kidney (MDCK) cells.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Chronic 3
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Synaptopodin is regulated by aromatase activity
Fester L, et al.
Journal of Neurochemistry, 140(1), 126-139 (2017)
Alberto Perez-Alvarez et al.
Nature communications, 11(1), 5083-5083 (2020-10-10)
In hippocampal pyramidal cells, a small subset of dendritic spines contain endoplasmic reticulum (ER). In large spines, ER frequently forms a spine apparatus, while smaller spines contain just a single tubule of smooth ER. Here we show that the ER
Expression of synaptopodin, an actin-associated protein, in the rat hippocampus after limbic epilepsy
Roth SU, et al.
Brain Pathology, 11(2), 169-181 (2001)
Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes
Mundel P, et al.
The Journal of cell biology, 139(1), 193-204 (1997)
Paula Merino-Serrais et al.
Cerebral cortex (New York, N.Y. : 1991), 33(4), 1074-1089 (2022-03-31)
At present, many studies support the notion that after stroke, remote regions connected to the infarcted area are also affected and may contribute to functional outcome. In the present study, we have analyzed possible microanatomical alterations in pyramidal neurons from
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