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About This Item
经验公式（希尔记法）:
C3H8N2O3
CAS号:
分子量:
120.11
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26
推荐产品
产品名称
DL-丝氨酸异羟肟酸酯, seryl-tRNA synthetase inhibitor
品質等級
化驗
≥97% (TLC)
形狀
powder
技術
ligand binding assay: suitable
顏色
white to off-white
應用
cell analysis
儲存溫度
−20°C
SMILES 字串
NC(CO)C(=O)NO
InChI
1S/C3H8N2O3/c4-2(1-6)3(7)5-8/h2,6,8H,1,4H2,(H,5,7)
InChI 密鑰
LELJBJGDDGUFRP-UHFFFAOYSA-N
應用
丝氨酸已被用作丝氨酰-tRNA 合成酶的抑制剂。 DL-丝氨酸异羟肟酸用于通过氨基酸饥饿诱导大肠杆菌中鸟苷 3′-二磷酸5′-二磷酸（ppGpp）的代谢合成。它还用于通过抑制 tRNA 装载来同步大肠杆菌培养物中的细胞周期。
生化／生理作用
丝氨酸参与单碳单位代谢。它与半胱氨酸、神经酰胺、磷脂酰丝氨酸、嘌呤和嘧啶的生物合成有关。在细菌中，它参与色氨酸合成。糖异生是重要的生化过程之一，涉及丝氨酸，尤其在反刍动物中。蛋白质磷酸化是利用丝氨酸的一种此类事件。甘氨酸是丝氨酸的代谢产物，可作为抗氧化剂和神经递质。已知 D-丝氨酸激活脑的 N-甲基-D-天冬氨酸（NMDA）受体。丝氨酸异羟肟酸，一种丝氨酸的结构类似物，它可阻止丝氨酸-tRNA（转移核糖核酸）装载，从而降低大肠杆菌的磷脂和核酸合成。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
D Riesenberg et al.
Journal of general microbiology, 130(10), 2549-2558 (1984-10-01)
The accumulation of RNA and protein and the kinetics of nucleoside triphosphate and guanosine polyphosphate pools during amino acid starvation and carbon source downshift were investigated in Streptomyces hygroscopicus. RNA accumulation was controlled stringently during both amino acid starvation and
M P Patricelli et al.
Proteomics, 1(9), 1067-1071 (2002-05-07)
The field of biochemistry is currently faced with the enormous challenge of assigning functional significance to more than thirty thousand predicted protein products encoded by the human genome. In order to accomplish this daunting task, methods will be required that
Daniel J Ferullo et al.
PLoS genetics, 4(12), e1000300-e1000300 (2008-12-17)
The bacterial stringent response, triggered by nutritional deprivation, causes an accumulation of the signaling nucleotides pppGpp and ppGpp. We characterize the replication arrest that occurs during the stringent response in Escherichia coli. Wild type cells undergo a RelA-dependent arrest after
David L Erickson et al.
Infection and immunity, 72(10), 5638-5645 (2004-09-24)
The stringent response is a mechanism by which bacteria adapt to nutritional deficiencies through the production of the guanine nucleotides ppGpp and pppGpp, produced by the RelA enzyme. We investigated the role of the relA gene in the ability of
I Weygand-Durasević et al.
European journal of biochemistry, 214(3), 869-877 (1993-06-15)
The Saccharomyces cerevisiae serS gene which encodes seryl-tRNA synthetase (SerRS) was expressed in Escherichia coli from the promoter and the ribosome binding sequences contained in its own 5'-flanking region. The low level of yeast SerRS in the prokaryotic host was
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