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种属反应性
human
技术
ELISA: suitable
assay range
inter-assay cv: <12%
intra-assay cv: <10%
运输
wet ice
储存温度
−20°C
一般描述
Sphingomyelin phosphodiesterase-1 (SMPD1) gene encodes for acid sphingomyelinase (aSMase), which is involved in the hydrolysis of sphingomyelin to ceramides and phosphorylcholine in the late endosomes and lysosomes. Ceramides act as proinflammatory and proapoptotic second messengers. Mutations in the SMPD1 gene are associated with a lack of aSMase, leading to Niemann-Pick disease type A and B. The SMPD1 gene is mapped to the human chromosome at 11p15.1–11p15.4.
应用
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
其他说明
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
储存分类代码
8A - Combustible corrosive hazardous materials
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Compound heterozygosity at the sphingomyelin phosphodiesterase-1 (SMPD1) gene is associated with low HDL cholesterol
Ching Y L, et al.
Human Genetics, 552?562-552?562 (2003)
Analysis of the sphingomyelin phosphodiesterase 1 gene (SMPD1) in Turkish Niemann?Pick disease patients: Mutation profile and description of a novel mutation
Ayukt A, et al.
Gene, 484-486 (2013)
Sphingomyelin phosphodiesterase 1 (SMPD1) mediates the attenuation of myocardial infarction-induced cardiac fibrosis by astaxanthin
Yu S, et al.
Biochemical and Biophysical Research Communications, 503(2), 637-643 (2018)
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