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物種活性
human
包裝
kit of 96 wells (12 strips x 8 wells)
技術
ELISA: suitable
capture ELISA: suitable
輸入
sample type plasma
sample type serum
sample type cell culture supernatant(s)
sample type urine
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.2 pg/mL
standard curve range: 0.205-50 pg/mL
檢測方法
colorimetric
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... CA9(768)
一般說明
Carbonic anhydrase IX (CA9) belongs to the zinc-containing metalloenzymes family. The protein is encoded by the gene mapped to human chromosome 9p. The encoded protein is localized on cell membrane and is characterized with an N-terminal proteoglycan-like domain (PG), a CA catalytic domain (CA), a transmembrane helical segment and a short intra-cytoplasmic tail. CA9 is expressed at very low levels in normal tissues (mostly in gastrointestinal tract), but it is expressed at high level in various cancer tissues, such as renal, lung, cervical, ovarian, esophageal and breast cancer.
The Human CA-IX (Carbonic Anhydrase IX) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human CA-IX in serum, plasma, cell culture supernatants and urine.
免疫原
Recombinant Human CA9
應用
请参考Protocol了解详情。
生化／生理作用
Carbonic anhydrase IX (CA9) aids in reversible hydration of carbon dioxide to carbonic acid and bicarbonate. CA9 functions as a promising biomarker for diagnosing clear cell renal cell carcinoma (ccRCC), tumor hypoxia and prostate cancer (PC). In addition to pH control, CA9 also plays a vital role in cell proliferation, adhesion and tumor invasion.
其他說明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
试剂盒组分也可单独购买
产品编号
说明
化学品安全说明书
訊號詞
Warning
危險聲明
防範說明
危險分類
Met. Corr. 1
儲存類別代碼
8A - Combustible corrosive hazardous materials
J E Lake et al.
HIV medicine, 15(7), 431-441 (2014-02-11)
Soluble CD14 (sCD14) is a monocyte activation marker associated with increased mortality in HIV infection. We assessed 48-week changes in sCD14 and other inflammatory biomarkers in virologically suppressed, HIV-infected women switching to raltegravir (RAL) from a protease inhibitor (PI) or
CA9 as a biomarker in preoperative biopsy of small solid renal masses for diagnosis of clear cell renal cell carcinoma.
Li G
Biomarkers, 22(2), 123-126 (2017)
D S Pisetsky et al.
Cytokine, 69(1), 110-115 (2014-07-16)
Anorexia nervosa (AN) is a serious, potentially life-threatening disorder characterized by severe weight loss, dysregulated eating, and often excessive exercise. While psychiatric illnesses such as depression are associated with increased levels of pro-inflammatory mediators, evidence for such disturbances in patients
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.
Hilvo M
The Journal of Biological Chemistry, 283(41), 27799-27809 (2008)
Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma.
La Rochelle J
Cancer, 116(20), 4696-4702 (2010)
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