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Merck
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文件

R7772

Sigma-Aldrich

核抑制剂

≥98% (TLC)

别名:

2-（R）- [[9-（1-甲基乙基）-6 - [（苯基甲基）氨基] -9H-嘌呤-2-基〕氨基〕-1-丁醇, 6-（苄基氨基）-2（R）- [[1-（羟甲基）丙基]氨基]-9-异丙基

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About This Item

经验公式（希尔记法）:
C19H26N6O
CAS号:
186692-46-6
分子量:
354.45
MDL號碼:
MFCD02266401
分類程式碼代碼:
12352200
PubChem物質ID:
24278682
NACRES:
NA.77

生物源

synthetic (organic)

化驗

≥98% (TLC)

形狀

powder

mp

106-107 °C

溶解度

chloroform: 50 mg/mL, clear, colorless to light yellow

儲存溫度

−20°C

SMILES 字串

CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1

InChI

1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1

InChI 密鑰

BTIHMVBBUGXLCJ-OAHLLOKOSA-N

基因資訊

human ... CDK1(983) , CDK2(1017) , CDK5(1020) , CDK7(1022) , CDK9(1025) , CDKN1A(1026) , CDKN1B(1027) , CDKN1C(1028) , CDKN2A(1029) , CDKN2B(1030) , CDKN2C(1031) , CDKN2D(1032) , CDKN3(1033)
mouse ... CDK1(12534)
rat ... CDK1(54237)

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應用

Roscovitine已用于：
  • 作为p34cdc2/cyclin B激酶抑制剂对猪卵母细胞进行预培养
  • 作为TCM199培养基的补充剂，用于成年山羊的卵-卵母细胞复合体（COC）的体外早熟化
  • 作为细胞周期蛋白依赖性激酶5（CDK5）抑制剂用于星形胶质细胞条件培养基中
  • 作为CDK2抑制剂加入培养基中以处理hESC细胞

生化／生理作用

Roscovitine是一种嘌呤衍生的抑制剂。它可刺激癌细胞的凋亡，对有丝分裂原活化蛋白激酶（MAPK）和M期促进因子（MPF）激酶活性具有抑制作用。Roscovitine已知可阻止减数分裂，从而阻止胚胎发育。
核抑制剂是细胞周期蛋白依赖性激酶的一种有效的、选择性抑制剂。

特點和優勢

《受体分类和信号转导》手册的 CDK 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物是细胞凋亡研究的推荐产品。点击此处了解更多特色细胞凋亡产品。在sigma.com/discover-bsm 上了解有关生物活性小分子在其他研究领域的更多信息。

法律資訊

经 CNRS 许可销售

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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Aftin-4 ≥98% (HPLC)

Sigma-Aldrich

SML1578

Aftin-4

Cdk2 Inhibitor III The Cdk2 Inhibitor III, also referenced under CAS 199986-75-9, controls the biological activity of Cdk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

238803

Cdk2 Inhibitor III

NU6140 ≥98% (HPLC)

Sigma-Aldrich

SML1323

NU6140

API-1

Sigma-Aldrich

SML1342

API-1

R547 ≥98% (HPLC)

Sigma-Aldrich

SML1254

R547

Qian Liang et al.
Scientific reports, 3, 2932-2932 (2013-10-15)
Epithelial-mesenchymal transition is a change of cellular plasticity critical for embryonic development and tumor metastasis. CDK5 is a proline-directed serine/threonine kinase playing important roles in cancer progression. Here we show that CDK5 is commonly overexpressed and significantly correlated with several
Bich Na Shin et al.
Scientific reports, 9(1), 13032-13032 (2019-09-12)
Abnormal activation of cyclin-dependent kinase 5 (Cdk5) is associated with pathophysiological conditions. Ischemic preconditioning (IPC) can provide neuroprotective effects against subsequent lethal ischemic insult. The objective of this study was to determine how Cdk5 and related molecules could affect neuroprotection
Eva Maria Putz et al.
Cell reports, 4(3), 437-444 (2013-08-13)
The transcription factor STAT1 is important in natural killer (NK) cells, which provide immediate defense against tumor and virally infected cells. We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against a range of tumor
Birth of piglets after transferring of in vitro-produced embryos pre-matured with R-roscovitine
Coy P, et al.
Reproduction (Cambridge, England), 129(6), 747-755 (2005)
Advances in Putrescine Research and Application, 4-4 (2013)
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