所有图片(1)
About This Item
经验公式（希尔记法）:
C21H27N7O
CAS号:
分子量:
393.49
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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方案
≥98% (HPLC)
表单
solid
溶解性
DMSO: soluble 7 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
C1CCC(CC1)Nc2nc(Nc3ccc(cc3)N4CCOCC4)nc5nc[nH]c25
InChI
1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)
InChI key
ZFLJHSQHILSNCM-UHFFFAOYSA-N
基因信息
human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)
rat ... Adora3(25370)
应用
逆转素已被用作单极纺锤体 1 (Mps1) 激酶抑制剂或有丝分裂纺锤体装配检查点 (SAC) 抑制剂：
- 研究康普瑞汀 A4 (CA4) 介导的细胞毒性是否需要有丝分裂阻滞
- 研究 SAC 活化对 eb 病毒 (EBV) 复制的贡献
- 诱导染色体错分
生化/生理作用
逆转素是一种 A 3 腺苷受体拮抗剂、Aurora 激酶抑制剂和 Mps1 激酶抑制剂。
逆转素最早被描述为一种合成的取代嘌呤，具有去分化剂的活性；它被证明可以诱导分化的谱系定向细胞成为多潜能间充质干细胞 (MSCs)。还显示出具有强效、选择性人 a 3 腺苷受体拮抗剂的活性（K i 值为 0.66μl）。ATP-竞争性 Aurora 激酶抑制剂，Mps1 激酶抑制剂。此外，研究表明，逆转素是一种抗癌药物，可抑制多种癌细胞的生长并诱导其死亡。
储存及稳定性
根据其他来源，在DMSO中储存的逆转溶液只能在短期内稳定冷藏。对于长期储存，等分试样应在-20°C下稳定保存最长2年。不建议溶液在常温下存放。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
G N Subramanian et al.
Molecular human reproduction, 27(2) (2020-12-19)
Premature loss of ovarian activity before 40 years of age is known as primary ovarian insufficiency (POI) and occurs in ∼1% of women. A more subtle decline in ovarian activity, known as premature ovarian ageing (POA), occurs in ∼10% of women.
Krishna K Sarangapani et al.
The Journal of cell biology, 220(12) (2021-10-15)
Dividing cells detect and correct erroneous kinetochore-microtubule attachments during mitosis, thereby avoiding chromosome missegregation. The Aurora B kinase phosphorylates microtubule-binding elements specifically at incorrectly attached kinetochores, promoting their release and providing another chance for proper attachments to form. However, growing
Chromosome mis-segregation generates cell-cycle-arrested cells with complex karyotypes that are eliminated by the immune system
Santaguida S, et al.
Developmental Cell, 41(6), 638-651 (2017)
Xianlong Chen et al.
Journal of bone oncology, 46, 100601-100601 (2024-05-06)
Reversine, or 2-(4-morpholinoanilino)-6-cyclohexylaminopurine, is a 2,6-disubstituted purine derivative. This small molecule shows anti-tumor potential by playing a central role in the inhibition of several kinases related to cell cycle regulation and cytokinesis. In this study, systematic review demonstrated the feasibility
Structurally simplified biphenyl combretastatin A4 derivatives retain in vitro anti-cancer activity dependent on mitotic arrest.
Tarade D, et al.
PLoS ONE, 12(3), e0171806-e0171806 (2017)
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