R0533

利福喷丁

• 别名: 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin, Cyclopentylrifampicin, DL 473
• 经验公式（希尔记法）: C₄₇H₆₄N₄O₁₂
• CAS号: 61379-65-5
• 分子量: 877.03
• EC 号: 262-743-9
• UNSPSC代码: 51283603
• PubChem化学物质编号: 329823987
• NACRES: NA.85

属性

• 方案: ≥93.5%
• 表单: powder or crystals
• 抗生素抗菌谱: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• 作用机制: enzyme | inhibits
• 运输: wet ice
• 储存温度: 2-8°C
• SMILES字符串: N5(CCN(CC5)C6CCCC6)N=Cc1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\C([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C(=O)N2)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O
• InChI: 1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23?/t24-,26+,27+,28+,33?,38-,39+,43+,47-/m0/s1
• InChI key: WDZCUPBHRAEYDL-OABFQHKQSA-N

说明

一般描述

Chemical structure: macrolide

应用

Rifapentine is an antibiotic clinically used to treat tuberculosis. It is used in tuberculosis research.

生化/生理作用

Rifapentine is a semisynthetic derivative of rifampicin with antibacterial activity against Gram-positive and Gram-negative bacteria and against Mycobacterium tuberculosis. Rifapentine inhibits DNA-dependant RNA polymerase and prevents RNA transcription. It interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.

Semisynthetic derivative of rifampicin with antibacterial activity against Gram-positive and Gram-negative bacterial and against Mycobacterium tuberculosis. Rifapentine inhibits DNA-dependant RNA polymerase and prevents RNA transcription.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H315,H319,H335
• 预防措施声明: P261 - P305 + P351 + P338
• 危险分类: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable