跳转至内容
Merck
所有图片(2)

文件

Q109

Sigma-Aldrich

6-Nitroquipazine maleate salt

solid

别名:

6-Nitro-2-(1-piperazinyl)quinoline maleate salt, Du 24565

登录查看公司和协议定价
所有图片(2)

About This Item

经验公式（希尔记法）:
C13H14N4O2 · C4H4O4
CAS号:
77372-73-7
分子量:
374.35
MDL號碼:
MFCD00153868
分類程式碼代碼:
12352202
PubChem物質ID:
24278116
NACRES:
NA.77

形狀

solid

顏色

yellow

溶解度

0.1 M HCl: 16 mg/mL
H2O: 5 mg/mL
methanol: 6 mg/mL
0.1 M NaOH: insoluble

儲存溫度

2-8°C

SMILES 字串

[H]\C(=C(/[H])C(O)=O)C(O)=O.[O-][N+](=O)c1ccc2nc(ccc2c1)N3CCNCC3

InChI

1S/C13H14N4O2.C4H4O4/c18-17(19)11-2-3-12-10(9-11)1-4-13(15-12)16-7-5-14-6-8-16;5-3(6)1-2-4(7)8/h1-4,9,14H,5-8H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI 密鑰

LXOHMGALVZOYRF-BTJKTKAUSA-N

基因資訊

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

生化／生理作用

Potent and selective serotonin transport blocker.

特點和優勢

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

K Hashimoto et al.
European journal of pharmacology, 187(3), 295-302 (1990-10-23)
The characteristics of the binding [3H]6-nitroquipazine, a very potent and selective inhibitor of 5-hydroxytryptamine (5-HT; serotonin) uptake, to human platelet membranes were studied at a physiological temperature of 37 degrees C. The presence of a single saturable high-affinity binding component
K Hashimoto et al.
European journal of pharmacology, 180(2-3), 273-281 (1990-05-16)
6-Nitroquipazine is a very potent and selective inhibitor of neuronal 5-hydroxytryptamine (5-HT; serotonin) uptake. We have characterized the specific binding of [3H]6-nitroquipazine to rat brain membranes at 22 degrees C. The present results indicate the presence of a single saturable
L Descarries et al.
Synapse (New York, N.Y.), 21(2), 131-139 (1995-10-01)
Direct counting of axon terminals (varicosities) labeled by uptake/storage of a tritiated monoamine provides a means to test radioligands of the corresponding membrane transporter as quantitative markers of regional monoamine innervation density in brain tissue. In autoradiographs from alternate rat
E Schlicker et al.
Naunyn-Schmiedeberg's archives of pharmacology, 342(5), 497-501 (1990-11-01)
Discs of pig retina were preincubated with 3H-noradrenaline, 3H-dopamine or 3H-serotonin and then superfused. Electrical field stimulation increased the outflow of tritium from discs preincubated with 3H-noradrenaline or 3H-dopamine, but no from discs preincubated with 3H-serotonin. The tritium content at
B S Lee et al.
Bioorganic & medicinal chemistry letters, 10(14), 1559-1562 (2000-07-29)
6-Nitroquipazine has been known as one of the most potent and selective inhibitors of serotonin transporter in vitro and in vivo. Nine derivatives of 6-nitroquipazine were synthesized and tested for their potential abilities to displace [3H]citalopram binding to the rat
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门