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Merck

P4562

Sigma-Aldrich

丙酮酸钠

powder, BioXtra, suitable for mouse embryo cell culture

别名:

α酮基丙酸 钠盐, 2-氧代丙酸 钠盐, 丙酮酸 钠盐

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About This Item

线性分子式:
CH3COCOONa
CAS号:
分子量:
110.04
Beilstein:
3568341
EC號碼:
MDL號碼:
分類程式碼代碼:
12352207
PubChem物質ID:
NACRES:
NA.75

產品線

BioXtra

化驗

≥99%

形狀

powder

技術

cell culture | embryo: suitable

mp

>300 °C (lit.)

溶解度

H2O: 100 mg/mL

儲存溫度

2-8°C

SMILES 字串

[Na+].CC(=O)C([O-])=O

InChI

1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1

InChI 密鑰

DAEPDZWVDSPTHF-UHFFFAOYSA-M

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一般說明

丙酮酸盐(pyruvate),糖酵解通路的终产物,是丙酮酸(pyruvic acid)的阴离子形式。

應用

丙酮酸钠可用于:
  • 作为精子培养Ca2+ + N三羟甲基甲胺基乙磺酸(TES)–NaCl溶液的补充剂
  • 作为TCM-199 hepes改良溶液的补充剂,用于卵丘卵母细胞复合体(COC′s)培养
  • 作为杜氏改良Eagle培养基(DMEM)补充剂,用于培养小鼠原代肝细胞(MPH),并用于腹腔注射禁食小鼠进行葡萄糖生成评估

生化/生理作用

丙酮酸钠主要用作培养基和肉汤组分。丙酮酸钠的抗氧化和抗炎作用可用于治疗过敏性鼻炎。丙酮酸钠还能用作乳酸中毒治疗的新药。
细胞将丙酮酸钠作为一种易于获取的碳水化合物来源。此外,它还参与氨基酸代谢并启动Kreb′循环。丙酮酸钠减弱体外氧化应激。 对于大多数细胞培养应用,应将100 mM溶液按1:100比例稀释。 该产品已被认证可用于小鼠胚胎培养。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Sens. 1B

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析证书(COA)

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Jing Yang et al.
Artificial cells, nanomedicine, and biotechnology, 44(1), 48-55 (2014-04-05)
To examine the effects of sodium pyruvate (SP) on metabolic acidosis. For the in vivo experiments, we evaluated effects of SP on an ammonium chloride (NH4Cl)-induced hyperchloremic acidosis rat model. SP was infused at overall doses of 2, 4, and
Maheul Ploton et al.
Journal of hepatology, 69(5), 1099-1109 (2018-07-08)
Embedded into a complex signaling network that coordinates glucose uptake, usage and production, the nuclear bile acid receptor FXR is expressed in several glucose-processing organs including the liver. Hepatic gluconeogenesis is controlled through allosteric regulation of gluconeogenic enzymes and by
Rangga Setiawan et al.
Animal reproduction science, 233, 106843-106843 (2021-09-15)
Adenosine triphosphate (ATP) production via glycolysis and oxidative phosphorylation is essential for the maintenance of flagellar motility in sperm; however, the primary energy production pathways supporting fertilization vary among species. Inconsistency in thought exists regarding which pathways maintain ATP production
Kyle S McCommis et al.
The Biochemical journal, 466(3), 443-454 (2015-03-10)
Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic pyruvate pools and rely
In vitro maturation of caprine oocytes in different concentrations of estrous goat serum
Kharche SD, et al.
Small Ruminant Research (2006)

商品

Milli-Q® 系统产出的超纯水不含BPA,适合用于胚胎学研究,最大限度地减少内分泌干扰物的干扰。

Ultrapure water from Milli-Q® system shown free of BPA, suitable for embryology research, minimizing endocrine disruptor interference.

用于转基因小鼠胚胎培养的小鼠胚胎培养基及经过胚胎培养验证的试剂

Mouse embryo media and embryo validated reagents for transgenic mouse embryo culture

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