P1319

促甲状腺素释放激素

≥98% (HPLC), powder

• 别名: L-焦谷氨酰-L-组氨酰-L-脯氨酰胺, TRF, TRH, pGlu-His-Pro 酰胺, 促甲状腺素释放素
• 经验公式（希尔记法）: C₁₆H₂₂N₆O₄
• CAS号: 24305-27-9
• 分子量: 362.38
• Beilstein: 770238
• EC號碼: 246-143-4
• MDL號碼: MFCD00038640
• 分類程式碼代碼: 51111800
• PubChem物質ID: 24898185
• NACRES: NA.32

属性

• 生物源: human
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 分子量: 362.38
• 儲存條件: (Keep container tightly closed in a dry and well-ventilated place)
• 技術: activity assay: suitable
• 雜質: 22.6-23.8% Nitrogen; 51.9-54.1% carbon
• 溶解度: water: 25 mg/mL, cloudy, colorless to faintly yellow
• UniProt登錄號: P20396; P21761; P34981
• 儲存溫度: −20°C
• SMILES 字串: NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3
• InChI: 1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
• InChI 密鑰: XNSAINXGIQZQOO-SRVKXCTJSA-N
• 基因資訊: human ... TRH(7200) , TRHR(7201) ; mouse ... Trhr(22045)

说明

Amino Acid Sequence

Glp-His-Pro-NH2

一般說明

Research area: Cell Signaling
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.

應用

Thyrotropin-releasing hormone has been used as a media supplement to study its effects on stimulating the secretion of prolactin (PRL) from somatolactotroph GH3 cells by enzyme immunometric assay. It has also been used to study its effects on the regulation of energy homeostasis in the central nervous system (CNS) in response to essential amino-acid deprivation.

生化／生理作用

Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.

促进垂体前叶生成和分泌促甲状腺素 (TSH)。

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)