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质量水平
方案
>97%
表单
solid
颜色
light yellow
溶解性
0.1 M HCl: 11 mg/mL
methanol: 2.5 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 5.0 mg/mL
SMILES字符串
CC1=C(CCN2CCC(CC2)C(=O)c3ccc(F)cc3)C(=O)N4C=CC=CC4=N1
InChI
1S/C23H24FN3O2/c1-16-20(23(29)27-12-3-2-4-21(27)25-16)11-15-26-13-9-18(10-14-26)22(28)17-5-7-19(24)8-6-17/h2-8,12,18H,9-11,13-15H2,1H3
InChI key
HXCNRYXBZNHDNE-UHFFFAOYSA-N
基因信息
human ... HTR2A(3356) , HTR2B(3357) , HTR2C(3358)
生化/生理作用
5-HT2 serotonin receptor antagonist.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
C Goodrich et al.
Physiology & behavior, 46(2), 203-209 (1989-08-01)
Experiments were designed to distinguish between central and peripheral effects on temperature preference and body temperature of drugs injected intraperitoneally (IP) in infant mice ranging in age from 3 to 10 days postpartum. These compared a drug restricted to the
L A Dykstra et al.
Psychopharmacology, 112(1), 116-120 (1993-01-01)
The kappa opioid, U50,488, was examined alone and in combination with the 5HT2 antagonists, ketanserin, pirenperone and LY 53857. Squirrel monkeys responded under a shock titration procedure in which shock intensity increased every 15 s from 0.01 to 2.0 mA
B Le Grand et al.
Journal of cardiovascular pharmacology, 26(5), 803-809 (1995-11-01)
Action potential duration (APD) lengthening is believed to underlie the cardiac arrhythmogenicity of ketanserin, a serotonin (5-HT)2A/2C receptor antagonist. We wished to determine (a) whether this activity involves blockade of 5-HT2A/2C receptors and (b) the precise mechanism of ketanserin-induced APD
J C Winter et al.
Pharmacology, biochemistry, and behavior, 62(3), 543-547 (1999-03-18)
Stimulus control was established in a group of nine rats using a dose of EGb 761 of 10 mg/kg, administered i.p., 15 min before training. A two-lever operant task using a fixed-ratio 10 schedule of sweetened milk reinforcement was used.
H J Altman et al.
Pharmacology, biochemistry, and behavior, 28(3), 353-359 (1987-11-01)
The experiments examined the effects of acute administration of three different serotonergic receptor antagonists (ketanserin, pirenperone and mianserin) on one-trial passive avoidance retention in mice. Administration of each antagonist 30 min before training produced a dose-dependent impairment in retention. In
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