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Merck

P1223

Sigma-Aldrich

二油酰基 L-α-磷脂酰乙醇胺

≥99% (GC), ≥98% (TLC), lyophilized powder

别名:

1,2-二油酰基-sn-丙三基-3-磷酸乙醇胺, 3-sn-磷脂酰乙醇胺, 1,2-二油酰, L-β,γ-二油酰-α-脑磷脂, DOPE, PE(18:1(9Z)/18:1(9Z)), 二油酰磷脂酰乙醇胺

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About This Item

经验公式(希尔记法):
C41H78NO8P
CAS号:
分子量:
744.03
Beilstein:
1718431
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.25

生物源

synthetic

品質等級

化驗

≥98% (TLC)
≥99% (GC)

形狀

lyophilized powder

官能基

phospholipid

脂質類型

phosphoglycerides

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC

InChI

1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-

InChI 密鑰

MWRBNPKJOOWZPW-CLFAGFIQSA-N

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應用

1,2-二油酰-sn-甘油-3-磷酸乙醇胺(DOPE)可与N-[1-(2,3-二油酰氧基)丙基] -N,N,N-三甲基甲基硫酸铵(DOTAP)形成异质脂质体而作为治疗剂的运载工具
与 DC-胆固醇(可用于有效转染几种哺乳动物细胞系)形成脂质体。

包裝

在氩气下包装。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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PLoS biology, 16(8), e2006357-e2006357 (2018-08-14)
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Journal of controlled release : official journal of the Controlled Release Society, 266, 109-118 (2017-09-26)
In this study, we investigated the potential of intradermal delivery of nanoparticulate vaccines to modulate the immune response of protein antigen using hollow microneedles. Four types of nanoparticles covering a broad range of physiochemical parameters, namely poly (lactic-co-glycolic) (PLGA) nanoparticles
Ernest Y Lee et al.
Nature communications, 10(1), 1012-1012 (2019-03-06)
Amphiphilicity in ɑ-helical antimicrobial peptides (AMPs) is recognized as a signature of potential membrane activity. Some AMPs are also strongly immunomodulatory: LL37-DNA complexes potently amplify Toll-like receptor 9 (TLR9) activation in immune cells and exacerbate autoimmune diseases. The rules governing
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Molecular therapy. Nucleic acids, 8, 459-468 (2017-09-18)
Synthetically modified mRNA is a unique bioactive agent, ideal for use in therapeutic applications, such as cancer vaccination or treatment of single-gene disorders. In order to facilitate mRNA transfections for future therapeutic applications, there is a need for the delivery

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