推荐产品
product name
泊马度胺, ≥98% (HPLC)
ligand
pomalidomide
品質等級
化驗
≥98% (HPLC)
形狀
powder
反應適用性
reagent type: ligand
顏色
yellow
溶解度
DMSO: ≥14 mg/mL
儲存溫度
2-8°C
SMILES 字串
Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
InChI
1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChI 密鑰
UVSMNLNDYGZFPF-UHFFFAOYSA-N
基因資訊
human ... CRBN(51185) , CUL4A(8451) , DDB1(1642) , RBX1(9978)
應用
泊马度胺已被用于：
- 处理BV173 细胞以研究蛋白质水解靶向嵌合体 (PROTAC) 化合物 JQ1-CRBN 在诱导特异性 I 类主要组织相容性复合体 (MHC-I) 肽中的作用
- 用于细胞凋亡研究和细胞内钙分析
- 作为胎儿血红蛋白 (HbF) 试剂用于研究 对& #946;-地中海贫血/变异血红蛋白 E (HbE) 红系祖细胞中胎儿血红蛋白表达水平与UNC0638 的累加效应
生化／生理作用
泊马度胺是一种有效的胎儿血红蛋白 (HbF) 诱导剂，可使关键的γ-珠蛋白抑制因子、SRY-box 转录因子 6 (SOX6) 和 BAF 染色质重塑复合物亚基 (BCL11A)下调。
泊马度胺是第二代免疫调节剂，TNF-α抑制剂和沙利度胺类似物。
特點和優勢
《受体分类和信号转导》手册的 细胞因子受体（肿瘤坏死受体家族） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
相關產品
产品编号
说明
价格
訊號詞
Danger
危險聲明
危險分類
Repr. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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We have previously shown that immunization with tumor antigen-loaded dendritic cells (DCs) and the immunomodulating drug, lenalidomide, synergistically potentiates the enhancing antitumor immunity in a myeloma mouse model. In this study, we investigated the immunogenicity of DCs combined with pomalidomide
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Emma C Fink et al.
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Thalidomide and its derivatives, lenalidomide and pomalidomide, are clinically effective treatments for multiple myeloma and myelodysplastic syndrome with del(5q). These molecules lack activity in murine models, limiting investigation of their therapeutic activity or toxicity in vivo. Here, we report the
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